Association Between Apelin Gene -1860T>C (rs56204867) Polymorphism and Coronary Artery Disease in a Syrian Cohort.

The statistical analysis revealed a highly significant difference in plasma apelin concentrations based on CAD severity (Mann–Whitney U = 843, p <0.001).

also in 132,142 other papers

Interestingly, while the C allele showed a borderline significant trend toward CAD risk in both males (OR=4.90, p=0.054) and females (OR=2.99, p=0.077), analyzing the combined total allele pool revealed a highly significant, independent 3.5-fold increase in CAD susceptibility (OR=3.56, p=0.009).

also in 231 other papers

In the male cohort, while the frequency of the mutant C allele was higher in CAD patients than in controls (12.9% vs 4.2%), the difference reached borderline significance after adjusting for age (OR = 4.90, 95% CI: 0.97–24.78, p = 0.054).

also in 370 other papers

In the female cohort, plasma apelin levels were slightly lower in individuals with the TC genotype [median: 2896 pg/mL (range: 422–5580 pg/mL)] compared to those with the TT genotype [median: 3286 pg/mL (range: 467–11950 pg/mL)], although this difference did not reach statistical significance (p = 0.305).

also in 111,027 other papers

These findings suggest that the APLN −1860T>C heterozygous genotype displays a strong trend toward an independent association with CAD susceptibility in the studied female Syrian population.

also in 5,725 other papers