Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease.

A number of studies in both healthy and sick individuals of different age and gender groups assessed its effect on Hcy or B-vitamin levels and found no or only marginal effects that failed to reach statistical significance [ 61 , 86 , 87 , 88 , 89 , 90 , 91 ].

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In addition, these doses slowed the increase in circulating levels of amyloid beta, a proposed indicator for amyloid plaque formation, even though it did not reach statistical significance [ 37 ].

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It had been proposed that insertion had no effect on the enzyme activity [ 109 ] and assessed on its own, its effect on Hcy is inconsistent: while some found no effect on Hcy [ 61 , 70 ], others showed a trend towards lower levels at least in specific subpopulations [ 59 , 60 , 66 , 89 , 110 ].

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There might also be an interaction between the different genotypes: in non-Hispanic whites homozygous for MTHFR 677T, there was a significant trend towards lower Hcy levels with increasing numbers of copies of 66G, which was not the case for the 677CC or CT genotypes [ 66 ].

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