Threshold for Pre-existing Antibody Levels Limiting Transduction Efficiency of Systemic rAAV9 Gene Delivery: Relevance for Translation.

Mol Ther Methods Clin Dev · 2019 · PMC6517378 · PMID 31193101

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

near-significantp = 0.062so close (0.05 < p ≤ 0.1)

Notably, near-significant negative correlations were observed between serum αAAV9 Abs and NAGLU activity in the intestine (p = 0.062) and muscle (p = 0.079; Figure 5 ).

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approached significanceno p-value reported

did not reach statistical significanceno p-value reported

Although tissue vg copy number and NAGLU activity level appeared to correlate in most of the tissues, further correlation analysis did not reach statistical significance, though the negative correlation in the spleen approached significance.

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showed a trendno p-value reported

Further correlation analyses showed a trend toward negative correlation between serum pre-existing αAAV9 Abs and tissue AAV vg copy levels in the brain, liver, heart, kidney, and lung ( Figure 4 ), though it did not reach statistical significance (p > 0.05).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.