Neoadjuvant strategies in resectable carcinoma esophagus: a meta-analysis of randomized trials.

[ 33 ] also showed a trend towards survival benefit with NACT, but this did not reach statistical significance.

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NART followed by surgery made a significant impact on a 3-year OS, reducing the risk by 42% (OR = 0.58 CI 0.39–0.86, p = .007) which continued to show a trend towards significance at 5 years.

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The 5-year OS did show a strong trend towards survival benefit but did not reach significance and can be interpreted in three disparate ways.

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There was a trend towards superior 3-year OS (OR = 0.85, 95% CI 0.68–1.06, p = 0.14) (Supplementary file 6 ) and 5-year OS (OR = 0.72 95% CI 0.49–1.07, p = 0.11) (Supplementary file 8 ) in favor of NACT, but it failed to reach statistical significance.

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This benefit diminished at 5 years (22%) as it only showed a trend towards statistical significance.

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