HLA-II Alleles Influence Physical and Behavioral Responses to a Whey Allergen in a Transgenic Mouse Model of Cow's Milk Allergy.

However, the difference in the scores between sham and BLG-sensitized mice was significant for DQ8 females (BLG DQ8: 0.6 ± 0.2; p = 0.04) and near statistical significance for DR3 females (BLG DR3: 0.7 ± 0.4; p = 0.07).

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While not statistically significant, BLG-sensitized DR3 males showed a clear trend for hypothermia (sham DR3: 36.5 ± 0.2°C; BLG DR3: 34.5 ± 1.0°C; p = 0.7) ( Figure 2C ).

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Disorganized villi and crypt structure were also noticeable in DQ8 male mice ( Figures 9C,F ), but the trend of decrease in their average villi length did not reach statistical significance ( Figure 10A ; sham DQ8: 292 ± 20 μm; BLG DQ8: 251 ± 23 μm).

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In addition, the sensitized DR15 females showed a trend for lower mobility than their sham counterparts ( Figures 3D–F ).

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