ACNP 61^st Annual Meeting: Poster Abstracts P271-P540.

Nominally significant CNV*PRS interaction effects included schizophrenia (B = -0.1, p = 0.03), brain surface area (B = -0.05, p = 0.04), autism spectrum disorder (B = 0.03, p = 0.02).

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Testing networks in NBS, we found a significant network negatively correlated with mood lability (5000 permutations, p = .004); a positively correlated network approached significance (5000 permutations, p = .055).

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The effect on prescreening visit attendance reached marginal significance, with participants in the experimental group being more likely to attend their prescreening visit (49%) than the control group (35%), X2 (1, N = 190) = 3.19, p = .074.

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PS males had the strongest correlation between PVT-NAc FC and anhedonia factor scores (0.77, p = 0.0054) where females did not quite reach significance (R = 0.3, p = 0.075).

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Results: A paired t-test showed a significant acute effect of rTMS over the left posterior area, with an increase of 37.825 in the weighted-node degree after five rTMS sessions (95% CI, 468 to 75.181); and marginally significant at the left frontal region (95% CI, -1.663 to 111.981).

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In the smaller subgroup of patients without baseline anxiety (n = 124), LS mean changes from baseline in MADRS total score were numerically greater for cariprazine 1.5 mg/d + ADT (-12.8) and 3 mg/d + ADT (-10.1) compared with placebo + ADT (-9.8), but LSMDs (95% CIs) versus placebo did not reach statistical significance for either cariprazine dose (1.5 mg/d = -3.0 [-7.3, 1.3], 3 mg/d = -0.4 [-4.5, 3.7]).

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Participants showed a trend towards decreased hippocampal DBSI restriction fraction (marker or inflammation) following PSIL exposure (linear mixed effects model, main effect of timexdrug; p = 0.08).

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