Excerpts

27 Although the published FSHB promoter polymorphism was not the strongest signal in this region, it was genome-wide significant for association with LH in our data ( P= 4.84 × 10 −9 ), and nearly significant for FSH ( P= 2.31 × 10 −7 ) ( Supplementary Table 11 ).

The GOEAST analysis only reveals some slightly significant overrepresented GO-terms, as, for example, the Molecular Function alpha-glucosidase activity ( P -value = 2.91E −7 ).

Twenty-five additional independent loci showed moderately significant ( P < 1 × 10 −6 ) associations, nine with endometrial cancer overall, nine specifically with endometrioid histology, and seven with non-endometrioid histology (Supplementary Data 2 ).

Within these 47 regions, we also assessed whether the traits that did not have a variant with p < 5 x 10 − 8 , had a moderately significant variant with p < 1 x 10 − 6 ; signals from such traits were also included in our fine-mapping.

For BRCA2 both ER and grade were highly significant predictors of mutation status, and the interaction of ER and grade was also quite significant (χ 2 = 28.3, 2 df , P <10 -6 ).

These differences were quite significant ( p < 1.7 × 10 −6 ) for every five participants.

Finally, GWAS from the CARDIOGRAM Plus consortium 23 identified a moderately significant association between a SNP overlapping the TCONS00016111 transcript and human coronary artery disease (P=4.78E–6) ( Fig. 6g ).

The next 2 genes (low density lipoprotein receptor ( LDLR ) and tissue inhibitor of metalloproteinases metallopeptidase inhibitor 1 ( TIMP1 ) showed moderately significant upregulation (p < 1 × 10 −5 ) in gene expression between D20+ TGF-β and D20 samples, as detected by RNASeq analysis and a significant upregulation at D20+ TGF-β vs D20 by real-time PCR (Fig. 4H,I ).

The identification of moderately significant (10 −2 >p>10 −5 ) SNPs offers a novel method for detecting the “missing heritability” of hypertension.

Device and catheter type: multi-seal mechanism devices: ICE significantly shortened duration (MD = −3.46, P < 0.00001), whereas single-seal mechanism had superior TEE (MD = 2.56, P = 0.0002), with a significant between-group difference between devices ( P < 0.0001); SoundStar catheters: ICE significantly shortened duration (MD = −4.90, P < 0.00001), other catheter types had insignificant or nearly significant differences, with significant differences between groups ( P < 0.00001). 3.4.2.4 Summarize security results A total of 16 studies were included, containing 1,673 patients in the ICE group and 5,266 patients in the TEE group.

Linkage disequilibrium and haplotype analysis The LD test revealed that LD was moderately significant between T182C and A3081T (|D'|=0.702, r 2 =0.275, p-value=<10 -5 ) but not between A3081T and G1287A or between T182C and G1287A ( Table 5 ).

After correcting for age at recruitment, population structure, and study site, we identified 266 moderately significant associations, 51 of which were independent ( p < 10 −5 , r 2 < 0.2).

Additionally, the Arg460Gly variant independently showed a moderately significant protective association with the heavy smoker phenotype (OR = 0.56; CI = 0.43–0.72; P = 1.1 × 10 −5 ).

Another haplotype located just 5′ to MSRA showed nearly significant over-transmission to individuals with MI, indicating that it conferred risk for MI (59 informative families, raw P = 1.99×10 −5 ; Bonferroni P = 0.057).

We found that this relation is quite significant (MIC = 0.54, p value ≤ 2e−5; see “ Analysis ” under the “ Methods ” section).

Results Correlation analysis between CNV values obtained with the two methods was slightly significant ( R = 0.413, p = 0.00002), because of the wider data dispersion in qPCR compared with ddPCR.

Among the 1509 successfully imputed SNPs in the SNCA locus, the strongest association was with rs2301135 (chr4:90,758,389, p = 5.68 × 10 −5 , OR = 1.40, minor allele C) and remained nearly significant after correction (threshold p < 3.3 × 10 −5 ) using conservative multiple test assumptions of independent SNPs.

(iii) Most of the disease LD blocks (67 %) included a single moderately significant disease-trait-associated marker (3E-08 < P < 3.3E-05).

For falling number, a nearly significant region was found on chromosome 7B ( p -value = 4.3 * 10 −5 ) with an allele frequency of 89% for the advantageous allele (Figure 5D ).

Moreover, 138 and 176 SNPs were found to have suggestive (moderately significant) association with RFI1 and RFI2 at p < 5 × 10 -5 , of which 124 SNPs have been found to be associated with both traits.

The association findings for these three genes using other methods (O’Brien with GATES and TATES with GATES) are also moderately significant ( P < 7.0 × 10 −5 ), except for MultiPhen with GATES ( P < 0.01).

These correlations were, however, quite significant at occipital electrodes: (meditation—O1, r = 0.77, P = 0.0001, O2, r = 0.71, P = 0.002; control—O1, r = 0.79, P = 0.0001, O2, r = 0.75, P = 0.001.

In addition, Spearman’s correlation analysis showed a moderately significant association between 2-methylbutyric acid and CHD development ( r = 0.5037, p = 0.0001).

One study reported a significant difference (MD: 25; 95% CI: 18.16–31.83; P = 0.0001), 27 , 30 and another found a moderately significant benefit (MD: 10.2; 95% CI: 5.91–14.48; P = 0.0001). 27 , 30 Two studies showed no significant differences ( P = 0.1622 and P = 0.2223, respectively). 26 , 36 Physical Well-being of the Chest The results were heterogeneous.

The linear regression analysis of the hospital stay relative to operator experience was quite significant statistically (p<0.0001) ( Figure 5 ).