Barely Significant

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If the 95% CI of corresponding EAPC estimation > 0, ASDR was recognized to be in an increasing trend, on the contrary, if 95% CI of corresponding EAPC estimation < 0, ASDR was recognized to be a decreasing trend, but if the 95% CI of corresponding EAPC including 0, ASDR was recognized to be stable.
When arguing on the age criteria using the following statements “The vaccine is most effective and protects best before the age of 14, when antibody production is optimal” and “The vaccine is most effective when administered before sexual debut”, we observed a positive trend on vaccine eagerness with the respective following coefficients [Coeff: 0.71; 95% CI: 0.33 – 1.09] and [Coeff: 0.37; 95% CI: 0.01 – 0.73].
Compared with nonsmokers, the HR (95% CI) for all-cause dementia events for those who started smoking before the age of 15 years, between 15 and 18 years, and at the age of 18 years or older was 1.33 (1.19–1.48), 1.15 (1.07–1.23), and 1.18 (1.10–1.27), respectively, showing a significant trend ( P -trend < 0.001).