Barely Significant

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There is clear and growing evidence linking the indiscriminate use of antibiotics within small- and large-scale agriculture to the development of antibiotic resistant microbes [ 67 – 69 ], and there is an increasing trend in the use of antibiotics for growth promotion and prophylaxis in commercial agriculture across LMICs.
There was also an increasing trend in the prevalence of clinical morbidities such as hypertension, atrial fibrillation, chronic kidney disease and type 2 diabetes, with increasing severity of obesity, such that individuals in the overweight-stable trajectory group had the lowest prevalence whereas those in obese class 3-stable trajectory group had the highest prevalence of comorbidities at baseline.
Both excess weight and depressive symptoms are more prevalent in people with higher socioeconomic income, found in the 4th quartile, while high blood pressure and diabetes are more prevalent among individuals of lower socioeconomic levels, with the highest being those in the 1st quartile. When observing the relationship between the four factors being studied and academic level reported by the surveyed Mexican population, a decreasing trend becomes evident for three of the factors (i.e. diabetes, high blood pressure and depressive symptoms), Fig. 4 , from lower to higher level of studies.
3 ), PR has a significant negative predictive effect on SPB for individuals with high HSE (M + 1SD) ( bsimple = − 0.51, t = − 14.65, P < 0.001); while for individuals with low HSE (M-1SD), PR also has a negative predictive effect on SPB, but its predictive effect is smaller ( bsimple = − 0.10, t = − 2.22, P < 0.05), which indicates that the predictive effect of PR on SPB tends to increase gradually with the enhancement of HSE. In addition, at the three levels of HSE, PR’s mediating effect on the relationship between SU and SPB also shows an increasing trend (see Table 8 ); that is, with the increase of individual HSE, SU is more likely to induce SPB by reducing public PR.
Another Cochrane review published in 2016 found that legislative smoking bans clearly lead to a reduction in exposure to SHS, strong evidence from the included studies supports a decline in admissions for acute coronary syndrome and a weak trend for a decrease in active smoking [ 30 ].