Excerpts

Patients with high PD-L1 expression on IC showed a trend for improved survival as assessed by IC area 25% alone ( Figure 2 D; not significant in multivariable survival models) and significantly improved DSS (5-year DSS rate: 61%; HR mult = 0.44 [95%-CI = 0.27–0.72]) and DFS (5-year DFS rate: 58%; HR mult = 0.42 [95%-CI = 0.26–0.68]) as assessed by Ventana IC5% ( Figure 2 E).

This is also reflected by the borderline significance of PD-L1 expression in multi-variable adjusted survival analyses in this study [ 36 ].

This was, however, only marginally significant and lacks justification why should minimally invasive surgery be a risk factor for LLL development.

Korean females have shown a decreasing trend of age at menarche and an increasing trend of height [ 74 , 75 , 76 , 77 ].

However, both the global incidence and mortality of CRC are expected to increase by 2030 due to an increasing trend in the CRC burden in many other countries [ 2 ].

pinnatifida , showed a significant trend toward an inverse association with the risk of overall CRC (odds ratio (OR), 95% confidence interval (CI) = 0.2 [0.0–0.9], P trend < 0.01) and rectal cancer (OR, 95% CI = 0.4 [0.1–1.1], P trend = 0.01) as a case-control study in Japan [ 184 ].

The significance level was set to p < 0.05, with p < 0.1 being evaluated as borderline significant.

[ 115 ] validated their radiomics-based model for EC patients receiving nCRT in an independent external cohort, which split risk groups for survival rates with borderline significance.

Patients stratified by ML models in different risk groups have a significant or borderline significant difference in survival outcomes.

With continued peptide dosing, there was a highly significant prolongation of survival time compared with controls.