Excerpts

Additionally, an assessment of tumor grade in neoplasia revealed an interesting trend [ 42 ].

It was observed that there is a decreasing trend in microbiota richness as the tumor grade increases.

Concretely, when CKD stages increase, prognostic grade groups show a decreasing trend, and conversely, when prognostic grade groups increase, CKD stages decrease.

[ 54 ] indicated an increasing trend for Streptococcus and Neisseria .

The incidence and mortality of colorectal cancer in China have shown an increasing trend.

The existing literature on this subject matter now provides compelling evidence pointing towards a statistical trend in favour of extended OS and PFS in cases involving craniotomy with resection, as opposed to the purely diagnostic stereotactic biopsy procedure.

The fourth important feature was the gray-level co-occurrence matrix Informational Measure of Correlation (glcm_Imc1 96 × 96), and it had a negative trend: a higher feature value resulted in a lower negative SHAP value.

In the last two decades, the availability of the robotic platform has created an increasing trend toward the minimally invasive surgical resection of HCC as large as hemihepatectomies [ 71 , 72 , 73 , 74 ].

In particular, our (near-significant) results regarding the analysis of adjuvant systemic treatment, as well as those of the separate analysis of subcohorts with different counts of treated metastases, could both benefit from larger sample sizes, in order to clearly define the potential influence of these factors on PFS and OS.

The distribution of cancer types shows an increasing trend over the last few years.

A significant trend observed in the literature was the application of machine-learning and deep-learning techniques for the diagnosis and prognosis of CC.

These tumors are largely resistant to calcitriol with only a slight trend towards smaller growth visible.

Among the variables analyzed, the type of anticancer drug used, categorized as C, CI, I, or M, emerged as a highly significant factor affecting 5-year OS.

LMWH showed a trend towards lower mortality rate (risk ratio (RR) 0.66; 95% CI, 0.40–1.10) and lower recurrent VTE (RR 0.69; 95% CI, 0.27–1.76) compared to UFH.

ICI type showed a marginal significance (0 = 0.0569) based on univariate model ( Supplementary Table S2 ).

Those with homogeneous staining showed a trend toward increased OS.

The results showed a favorable trend in OS in the preoperative CXRT group, although there was no statistically significant difference in either 3-year or 5-year OS rates because of the small number of enrolled patients [ 20 , 21 ].

Introduction Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in importance among head and neck cancer (HNC), as a significant increase in incidence has been observed, whereas head and neck squamous cell carcinoma (HNSCC) has shown a decreasing trend worldwide.

While the incidence of CRC for ≥50 year-old adults showed a favorable trend in recent years, the incidence recently increased in the group of young adults (<50 years-old) in multiple high-income countries [ 1 , 2 , 3 , 4 ].

We achieved the highly significant identification of regulated genes across multiple cell lines either exposed or not to the same drug, and were able to accomplish this using frozen samples from lines harvested at different times.

As shown by our data, we found significantly reduced levels of PLK5 protein in lung, cervical, ovarian, and fallopian tube cancers, and a decreasing trend towards significance in endometrial and testicular cancer tissues ( Figure 2 B).

Over the past few years, we have observed an increasing trend of publications on radiomic approaches in oncology [ 11 ], especially for predicting diagnosis [ 12 , 13 , 14 ] and treatment response [ 15 , 16 , 17 , 18 , 19 ], as well as tumor molecular profiles [ 20 , 21 ].

The most recent available data from a systematic review and meta-analysis of 80 studies from the Eastern Mediterranean Region (including Qatar, Kuwait, Oman, Bahrain, and the UAE) reported a pooled ASR of 37.1 per 100,000 person-years (95% confidence interval (CI), 34.5, 39.8) during 2011–2019 and an increasing trend between 2005 and 2019.

Despite using forward and backward stepwise selection, we failed to develop a multivariable logistic regression model with more than one statistically significant variable, probably due to multiple, highly significant interdependencies between the analyzed factors, as demonstrated in the Spearman’s rank correlation analysis ( Table S2 ).

We showed an association of the EASIX, s-EASIX, and a trend towards significance for the m-EASIX calculated at pre-LD with ICANS grade ≥ 2, although the predictive performance of these scores is only moderate.