Barely Significant

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From the PARALLEL-HF study's randomization to the pre-specified time points of week 8 (LSM change from baseline for sacubitril/valsartan versus enalapril: 0.05 versus 2.59; p = 0.1854) and month 6 (2.22 versus 3.49; p = 0.5737), sacubitril/valsartan showed a trend to a lesser deterioration of KCCQ clinical summary score for HF symptoms and physical limitations [ 48 ].