Barely Significant

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quite significantqualifiedgold
osis [ 1 - 3 ].​ The somatic mutation JAK2 V617F, a single nucleotide polymorphism, is present in most patients with PV and MPNs, and in 50% of patients with ET ​[ 4 - 7 ].​ Given the prevalence of PV and ET, which have an incidence between 38 and 57 per 100,000 people in the United States, this is quite significant ​[ 8 ].​ In addition, those with PV and ET have a significant burden due to their hypercoagulable state with associated major thrombosis in 20% to 50% at the time of diagnosis ​[ 9 , 10 ].​ This increased hypercoagulable state can lead to the development of portal thrombosis and hypertension, giving rise to Budd-Chiari Syndrome (BCS) [ 11 ].
In a post-hoc analysis conducted by Reck et al., an encouraging trend toward prolonged median OS was observed (NE vs. 17.5 months, HR = 0.39 (95% CI, 0.14-1.07)), alongside a statistically significant improvement in median PFS (9.7 vs. 6.1 months, HR = 0.42 (95% CI, 0.22-0.80)) when comparing ABCP with BCP.