Excerpts

The RAND-36 questionnaire results showed a trend toward improved physical function in the intervention group, as compared to the placebo. bLF has been shown to prevent arthritis in experimental animal models ( 48 ).

A slight trend toward increased branching and average process length and volume were noted in combination-treated mice.

Importantly, B-I09 also significantly reduced xenogeneic GVHD by the human T cells against murine liver (Figures 6A,C ) and modestly against mouse lungs that did not quite reach statistical significance (Figures 6A,D ).

Moreover, the hemocyanin content of all the diet groups showed a trend of reduction at 24 h compared with 12 h after A. hydrophila injection.

Whilst they may not be as effective at antigen presentation as typical antigen presenting cells their overall impact may be significant due to their sheer numbers [reviewed in ( 4 )].

Seven week-old Npc1 nih mice that received the immunization demonstrated reduced levels of hepatic total cholesterol (Figure 3A ) and triglycerides (Figure 3B ) compared to control-treated Npc1 nih mice, though the latter only showed a trend.

Additionally, we showed a trend of increased IgG Fc agalactosylation in inflammatory-mediated diseases of preterm infants (i.e., chronic lung disease) supporting the hypothesis of a pro-inflammatory effect.

Consistent with the above findings, neutrophil-mediated ADCC of SKBR3 cells using afucosylated trastuzumab resulted in a highly significant and prominent (up to ~80–90%) decrease in ADCC when compared to normally fucosylated trastuzumab ( Figure 4A ).

We found a higher percentage of H2D b -GP33-41 + CD8 + T cells in NFAT1 KO mice while NFAT1/2 DKO mice showed a trend of reduced frequency and significant decreased total numbers of H2D b -GP33-41 specific CTLs compared to WT controls ( Figures 2A,B , S2B – D ).

Recently, we have seen an increasing trend in the number of positive trials in which XRT is used to treat up to three metastatic sites.

Nevertheless, a substantial increase in lymphoproliferative response, in comparison to infected control, was evident only in the lymph node cells of hamsters vaccinated with P-15+BCG (0.3175 ± 0.027) on day 60 p.c., whereas by day 90 p.c., this response was found to be highly significant in all the three peptides+BCG vaccinated groups i.e., P-10+BCG (0.3931 ± 0.014), P-14+BCG (0.4533 ± 0.008), and P-15+BCG (0.4551 ± 0.022) which was in accordance with the DTH response ( Figure 3C ).

Among the pre-Ty21a time-point, clusters 9, 11, 13, 18, and 19 are significantly more abundant in children, while only cluster 3 is significantly higher in adults (with clusters 7 and 10 trending toward significance; Figure 6B ).

Importantly, patients with SLE did not show any significant difference in these immunosuppressive molecules, although showed a trend to have lower serum levels ( Figure 5 ).

As the animals got older, there was a highly significant decrease from 3 to 25 weeks of age (mean 2.7%); thereafter, lower but significant increases were seen at 26 months and 4 years of age.

On the other hand, within the same time frame, IgG treatment showed a trend for increased tumor growth, as previously reported ( 29 ).

As shown in Figure 8 , TAC and MePRD reduced the secretion of IFNγ significantly by 71.1 ± 24.5% and 95.6 ± 5.5%, respectively; whereas MPA and EVE by 42.4 ± 19.8% and 42.9 ± 15.3%, respectively, CsA-induced changes were barely significant (27.3 ± 12.16%) ( Figure 8A , left panel).

In contrast, IVIg showed a trend toward increased IFNγ production and secretion.

PC-3 cells also showed a strong and highly significant increase in the expression of MICB and ULBP-2/5/6, however the increase in MICA expression was only moderate but still significant after 5 mM and 2.5 mM VPA treatment ( Figures 2A–C ).

By contrast, a near-significant increase in corneal CD11c + cells was observed in I/F8-Fc treated mice, suggesting a role of ALCAM blockade in the retention of antigen-presenting DCs in the cornea ( Figures 6F,G ).

2DG, but not CG-5, showed a trend toward reduced B cell proliferation.

There was a highly significant overlap of up-regulated or down-regulated genes between poly(dA-dT) and poly(I:C) treatment groups ( Figures 2A,B ), indicating that the dsDNA and dsRNA viral infection induce common transcriptome changes.

One remarkable feature emerged was the steady and highly significant increase in the mean protein concentration of complement C4 from non-APS (16.6 ± 8.8 mg/dL), to extended APS (20.0 ± 9.2 mg/dL), and definitive APS (22.9 ± 10.0 mg/dL) ( p = 2.6 × 10 −8 ).

There was a decreasing trend of IL-35 level in the serum post-TACE, however, this difference failed to achieve statistical significance (23.43 ± 3.33pg/mL vs. 20.19 ± 4.36 pg/mL, paired t- test, P = 0.072, Figure 1F ).

In addition, we identified marginally significant ASB to enhancer mark H3K4me1 at SNPs rs6495979 and rs7170151, which tagged a regulatory region within ~500 bp ( Supplementary Figure 4b ).

Patients with active disease not comprising any vascular involvement (V.I.) and patients with active vascular involvement in SLE showed a trend toward higher PTX3 levels compared to patients with clinically quiescent disease.