Conversely, the treatment caused a highly significant ( p < 0.0001) decrease in Pol, Tax, and HBZ expression with respect to the untreated control in PB2/NO-IL-2 cells.
Excerpts
GDF-15 showed the most robust response, with highly significant main effects for both time and dose and a strong interaction ( p < 0.0001).
Two-way repeated-measures ANOVA analysis showed an extremely significant drug effect ( F (4, 329) = 8.571, p < 0.0001) and time effect ( F (4, 329) = 8.571, p < 0.0001).
There was also a highly significant ( p < 0.0001) effect of temperature on cytoplasmic ROS levels after 6 and 12 h IVM.
These findings were highly significant in all cases ( p < 0.0001).
Treatment with haloperidol increased the lysosomal pH in a dose-dependent manner, an effect that was highly significant ( p < 0.0001) with doses of 10 (6.56 ± 0.24, mean ± SEM, n = 15) and 25 μM (8.18 ± 1.46), but not with 5 μM (4.21 ± 0.41) ( Figure 2 ).
The Kruskal–Wallis test for the lateral region was highly significant ( p < 0.0001).
This trend was progressively accentuated at weeks 8 and 12 (W8, W12), when the differences between DM+ and DM– were highly significant ( p < 0.0001).
Migration assays revealed that both lyophilized and fresh PRF caused a highly significant ( p < 0.0001) 15- to 20-fold increase in the number of migrated cells when compared to DMEM medium ( Figure 2D ).
The SiO 2 content in the hybrid materials is described by a statistically highly significant model ( p < 0.0001) with a high robustness R2 pred = 0.9459 and, hence, a good predictive power ( Table 2 ).
Only the experimental group of combined CIP with PIC maintained a highly significant difference ( p < 0.0001) within 24 h for these two strains.
Among 48 cytokines/chemokines, evaluated by multiplex analysis in patient plasma, 6 (IL-6, CXCL-10, HGF, MIG, MCP-1, and G-CSF; Supplementary Table S2 ) were identified as highly significant in COVID-19 patients compared to non-COVID-19 respiratory disease controls ( p -value < 0.0001) ( Figure 2 ).
In the case of the SKOV-3 cell line, with high HER2 expression, a saturation of HER2 with an excess of unlabeled proteins resulted in a highly significant ( p < 0.0001 in unpaired t -test) reduction of binding of both proteins.
Concerning p -values, the results were highly significant for the protein when stored at 4 °C for all the tested conditions ( p -value < 0.0001), and significant when the protein was stored at −80 °C ( p -value < 0.05 and p -value < 0.01).
However, when only pCx43 colocalized with PDGFRB was expressed, a highly significant decrease in expression was found, at the level of p < 0.0001 ( Figure 11 ).
While KRT20 mRNA tended to be positively associated with pCR status (r = 0.3072; p = 0.0684), the negative association of FGFR1 mRNA expression with pCR status was highly significant (r = −0.65418, p < 0.0001). 2.3.
The statistical difference was highly significant for both LVIDDn (Kruskal–Wallis test, p < 0.0001) and LA/Ao (Kruskal–Wallis test, p < 0.0001).
The differences between the animals that do not suffer degenerative processes (C57 and Opn4 −/− ) and the models with retinal degeneration (Rd10 and O×Rd) are extremely significant (two-way ANOVA, p < 0.0001).
We tested the associations of the vaccine-induced responses with measured serum neutralizing titers (NT 50 ) and observed strong and highly significant correlations, the highest with P3-II (Spearman CC = 0.88, p < 0.0001, Figure 5 A).
In contrast, the LGG cohort showed highly significant separation of survival curves, with the low-risk group demonstrating markedly improved outcomes ( p < 0.0001) ( Figure S3E ).
The CLEC treatment provided an accelerated wound closure that was highly significant ( p < 0.0001) over time compared to the other two treatment arms.
Upregulation of miR-132-3p led to a small, but consistent, enhancement of NMT2 expression (118%) whereas down-regulation of miR-132-3p was associated with a highly significant decrease in NMT2 expression (39%) ( p = 0.0001).
The difference between the mean radiation-induced G2 scores for 0.05 Gy compared to 0.5 Gy in this cohort were highly significant (two-tailed p value < 0.0001) by the Mann–Whitney test and this is also illustrated in Figure 1 for both doses in the healthy control donors.
A meta-analysis based mainly on the findings of six studies pertaining to treatment with clozapine supported a significant overall beneficial effect on suicidal behavior, with a highly significant ( p < 0.0001), 3.3-fold [CI: 1.7–5.7] lower pooled risk of suicidal behaviors with clozapine compared to alternative treatments [ 41 ].
Figure 10 shows that the control group had a glomerular mesangial mean area of 3219.3 μm 2 , while rats with DN had a mean of 5659.7 μm 2 , which is a highly significant difference (**** p < 0.0001).