Excerpts

First, we investigated the possible role of DRB1*03:01 in MS susceptibility and we observed a highly significant effect: OR = 1.52, 95% CI 1.23–1.88, p = 7.1*10 −5 .

For the H3K4me3 mark, the separation at the level of PC1 = 0 was highly significant (p = 7.6x10 -5 , Fig 2A ), but not at lower PCs (see PC1 to PC5 in S3 Fig ).

The Student's t-test of the differences in 13 C enrichment at 20–60 min after the pulse and in the initial 13 C accumulation rate at 0.5–10.0 min showed that these differences were highly significant in both cases, p = 0.00008 and p = 0.050, respectively.

SOX4 , the most proximal gene showed a highly significant association between gene copy numbers and gene expression (ρ = 0.59, p<8×10 −5 ), as did CDKAL1 (ρ = 0.78, p<3×10 −16 ).

The highly significant association ( P ≤ 8.17 × 10 −5 ) between seed length to width ratio and TcSNP 733 on chromosome 5 was verified with FarmCPU ( P ≤ 1.12 × 10 −8 ).

Also, although the association between rs174548 and FADS1 was nominally significant in tissues such as whole blood and subcutaneous adipose tissue, the associations did not reach the multiple testing correction threshold (FDR<0.05, p≤ 8.30x10 -5 ).

Remarkably, PRRT2 displays a highly significant excess of nonsynonymous (pN) vs synonymous (pS) mutations in Asia (pN/pS = 4.85) and Europe (pN/pS = 1.62) compared with Africa (pN/pS = 0.26; Asia vs Africa: P = 0.000087; Europe vs Africa P = 0.00035; Europe vs Asia P = P = 0.084).

yakuba ( P = 0.0291) and highly significant for D. simulans ( P = 9.044 × 10 −5 ).

All the probes shown in Figure 2 were highly significant with p-values <9.77E −05 .

There was a strong and highly significant correlation between virus titers measured by TC-LDA and qRT-PCR (R 2 = 0.89, P <0.0001; Figure 5 ) and the slope of the line indicates that there is approximately a 1∶1 relationship between the number of infectious virus particles and virus genome equivalents identified in these serum samples.

This difference was determined to be highly significant (p<.0001; number of trials = 1500; number of successes = 1139) using a binomial test and therefore the accuracy in estimating land cover actually increased in the final stages of the competition.

and C.H.] and a high Spearman correlation coefficient ( = 0.82) and a highly significant (p<0.0001) correlation between measurements was observed.

mansoni cathepsin B1 (SmCB1), or a cathepsin L from a related parasite Fasciola hepatica (FhCL1), elicits highly significant ( P <0.0001) protection (up to 73%) against an experimental challenge worm infection.

The correlation coefficient between LCT*P frequencies and latitude was highly significant ( r = 0.274, p <0.0001).

By two-tailed t-test, all markers exhibited highly significant (P<0.0001) decrements in immunoreactivity in the AD twin compared to the ND twin ( Figure 2b ).

The correlation between change in HbA1c and level of HbA1c at start of treatment with HCQ was highly significant (correlation coefficient -0.77, p<0.0001).

The results are highly significant (p<0.0001, Table 2 ), and indicate that MYC IHC can identify a set of tumors with transcriptional profiles resembling those previously categorized as mBL.

The result of a trend test indicated there was a significant trend difference between TBI with ESRD patients and patients without ESRD ( p <.0001).

The difference between median value of C PRSA and C RAW was highly significant (0.79 [IQR 0.69–0.90] and 0.29 [IQR 0.17–0.47], respectively; p<0.0001).

Any regional overlap (within 20 kb) of EWAS and GWAS signals of at least marginal significance (defined as P <1.0*10 −4 ) was identified.

The haplotype (07–501) showed highly significant effects (p<0.0001) on all the three non-return rates.

The multiple regression model for color was highly significant (R 2 = 0.84, F 3,110 = 188, P <0.0001), but the slope and intercepts were affected by ecosystem type, which resulted in the following equations: (2) and (3) Despite the differences in the regression parameters, most of the color observations from the experimental ponds fell within the 95% prediction intervals associated with the regression model for natural lakes in equation 3 ( Fig. 2a ).

Tadpoles in full water volume took on average 105.5 days (± 4.0 SE) to reach Gosner stage 38 and 132.65 days (± 4.25) to reach metamorphosis (Gosner stage 42), whereas tadpoles exposed to low water volume took 86.38 days (± 4.43) to reach stage 38 and 89.77 (± 4.0) days to reach metamorphosis, resulting in highly significant reductions in larval period ( F 1,44 = 23.20, P < 0.0001 for days to Gosner stage 38; F 1,45 = 40.91, P <0.0001 for days to Gosner stage 42) ( Figure 2A ).

It shows that the major source of variation was the gene factor, and that there was a highly significant interaction between the gene factor on the one hand, and time, TNF or PL on the other hand (P<0.0001), whereas the interaction between the gene factor and RBC appeared to be weaker (P = 0.04).

ANOSIM comparisons indicated highly significant (p≤0.0001) differences among strata in the distribution of ant genera and species diversity, and NMDS analysis showed clear separation between the three strata ( Figure 2 ).