Barely Significant

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Kidney injury was also observed due to a significant increase in serum creatinine levels and an increasing trend in urea levels in the untreated group, while a protective effect was exhibited in the mice receiving chitosan@DOTAGA treatment, who displayed normal kidney function.
Specifically: I do not completely agree with conclusions of the results as stated by authors In the results section When results are not significant, not sure we can there is a positive trend ( especially when the total N is also very low), So not sure if we can come to this conclusion -Ex” Lef atrial volume and Sys pulm artery pressure: P is 0.6 and 0.26 with only minimal change in pulm artery pressure?).
Most notably, there was a dramatic increase in the probability of an R/S event at the start of the first wave of the COVID pandemic in Ontario, beginning with a 3.6% increase in April 2020, followed by a decreasing trend in the magnitude of the R/S probability change in May (2.5%), and June (1.4%) of 2020, with R/S probability returning to levels comparable to those before the onset of COVID by July of 2020 (> 1% increase in R/S probability; Table 1 and Fig 4 ).
From 2003 to 2018, the growth of winter wheat in northern Henan from the trefoil stage to the milky stage showed a trend of shortening, consistent with the relevant research results [ 32 , 33 ]. 4.4.2 Differences in regional changes of the phenological stages in northern Henan The average regression slope value of each city in the northern Henan was calculated to evaluate the difference of changing trend of phenological periods in the cities ( Fig 7 ).
2.3 Selection criteria for filtered candidate miRNAs and mRNAs The selected miRNAs and mRNAs should have a strong association with both BC and other cancers in the literature (keywords such as "gene name, miRNA name, cancer, breast cancer, breast" were searched in the PubMed database), A distinct altered expression level of these mRNAs should be detected across all of the PAM50 subgroups from normal-like to the BLBC with an increasing trend in the form of a pan flute.