Excerpts

While these are also small studies, these results may be significant given that the expected progression-free survival is 6.9–8.2 months in this patient population [74] , [75] .

Although several nutrients were associated with risk of CE in the basic multivariate model, most notably monosaccharides and fiber in both men and women (both negatively), no nutrients retained significance in the full model, although the protective fiber association in women was of borderline significance ( p for trend = 0.067).

Only the protective association with fiber in men ( p for trend = 0.050) remained borderline significant after full adjustment.

A substantial and highly significant reduction in the percentage of p21 CIP1/WAF1 positive cells was seen upon knockdown of three of the validated targets, PRPK/TP53RK, the MAPK pathway component STK4/MST1 and CDK4 ( Figure 3A, C ).

Demonstration that an observed trend controls diversity would be infeasible outside multiple generation studies under tightly controlled experimental conditions, conditions that might have little relevance to field settings.

The difference in survival time between Mock/MYC mice and FLIP L /MYC was not statistically significant whereas the difference in survival times between Mock/MYC and BCL-X L /MYC mice was highly significant ( Table 1 ).

We considered a ratio of 1.5 to be highly significant based on the assumption that one of the two Notch1 alleles produces the cryptic transcripts at the same level as the full-length species.

We observed a highly significant linear relationship between forest-derived OC and the net increase of OC in afforested soil ( Fig. 6 ).

In fact, the responses to the two antigens were correlated with a highly significant Spearman's correlation coefficient of >0.7.

The corresponding difference between individuals in SSA and non-African Europeans became more pronounced and was highly significant; the difference in slopes between non-African Europeans and Europeans - African origin became attenuated and was no longer significant.

Despite widespread clinical use of GKRS for the treatment of TN, there are no objective imaging methods to adequately correlate treatment and outcome, particularly since TN GKRS is associated with delay in pain relief [8] and a relatively lower risk of facial dysesthesia compared with other TN treatments [9] , although more recent reports demonstrate an increasing trend of facial dysesthesiae with time [10] – [12] .

The ecological and physiological consequences of this variability are poorly understood, though they may be significant and complex.

In addition, the growth reductions in all but the northernmost counties were found to be marginally significant, which is noteworthy considering that the available time series were relatively short (n = 56) compared to the recommendations for interrupted ARIMA analysis [26] .

Moreover, while Norway spruce growth anomalies (after controlling for the influence of climate) in the years 2005–2007 showed a positive trend for the rest of Sweden they decreased in the counties affected by Gudrun ( Figure 3a,b ).

The younger male Dig showed a trend to intervene preferentially in male-male conflicts compared to the other classes (see Fig. 2b ).

[15] found little evidence of taxonomic distinctiveness between the two subspecies, based on a phylogenetic reconstruction of mtDNA sequences, but did find highly significant differentiation between the three Southern Hemisphere populations based on mtDNA haplotype frequencies and a high probability of population assignment using seven microsatellite loci [15] .

However, for HIV-1 BAL there was a significant trend of enrichment in transmitted variants, regardless whether the identical sequences were removed or not for the analysis.

However, because the number of replicate sites that we studied was modest and because we were concerned about falsely rejecting the hypothesis that oil exposure affected our response variables, we considered p-values between 0.05 and 0.10 as marginally significant and indicative of strong trends.

jensenii colonized cultures did not show significant reductions following PIC application although there was an apparent trend.

Some ethnic backgrounds retained marginal significance, in particular Gypsies (aOR 8.26, CI 1.03–66.34) and Amerinds (aOR 2.30, CI 1.16–4.58).

Identification of such markers might be significant in profiling the circulating tumor cells and predicting the patterns of metastasis in patients.

sapiens mean is not significant for all PCs (PC 1 z -0.89; PC 2 z 0.95; approaching significance for PC 3 z 1.70, p 0.05).

In our study we found a highly significant male-female interaction for mating speed that persisted without the Zimbabwe line and evidence for strong behavioral reproductive isolation between the Zimbabwe and Beijing lines.

Patients scored significantly worse regarding psychological symptoms in general (BSI, Global Severity Index) as well as on seven of the nine specific subscales with the other two approaching significance.

Results We were not able to observe a statistically significant TCD effect in the EEG data of the whole patient group, but a subsample of patients with evidence for root damage showed a trend in this direction.