Barely Significant

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a decreasing trendP = 0.000a p-value is never exactly 0gold
nd significant increasing trend was observed in age ( P = 0.001), BMI ( P = 0.000),SBP ( P = 0.000), AST ( P = 0.000), BUN ( P = 0.000), serum CR ( P = 0.000), SUA ( P = 0.000), TC ( P = 0.007), TG ( P = 0.000), VLDL ( P = 0.000), FINS ( P = 0.000), P2INS ( P = 0.000), and HOMA-IR ( P = 0.000), but a decreasing trend in eGFR ( P = 0.000) and glycated HbA1c ( P = 0.001).
highly significantp -values = 0a p-value is never exactly 0qualifiedgold
With 10,000 iterations of random shuffling of the enhancer predictions in the H1 genome, we found the average validation rate of distal DHS, p300 and TF to be 13.0%, 1.1% and 4.2%, respectively, and the actual validation rates were highly significant according to a one-sided t -test ( p -values = 0) ( Fig. 1B ).
highly significantp < 0.00000a p-value is never exactly 0qualifiedgold
This difference was statistically highly significant ( p < 0.00000 after applying the Benjamini–Hochberg correction), which suggests a decreased proteasomal activity in patients with PKU who have the rs113883650 variant in the condition of hyperphenylalaninemia requiring dietary adjustment (600 μmol/l).
highly significantP = 0.000a p-value is never exactly 0qualifiedgold
4 ) In the current study, the administration of CDDP to rats caused nephrotoxicity, as shown by the highly substantial elevation in serum urea and creatinine, renal MDA and NO, with highly significant reduction in creatinine clearance and renal PON 1( P = 0.000) compared to the control group.
highly significantp ~ 0a p-value is never exactly 0qualifiedgold
Moreover, mediation analysis in which the direction of causation in the model is reversed, i.e., to explore whether motor deficits mediate between disease duration and cerebral WM FA, we find only weak evidence of this mediation effect (δ = − 0.0003, CI 95% = − 0.0007 to 0, p = 0.06), while the direct path between disease duration and cerebral WM FA remains highly significant (ζ = − 0.0014, CI 95% = − 0.0022 to 0, p ~ 0).