Excerpts

Results The results showed highly significant correlations between the TAS-26 subscale “difficulty in identifying feelings” and the ERQ scale “suppression” (r = 0.5; p < 0.001) and between the TAS-26 subscale “difficulty in describing feelings” and the ERQ scale “suppression” (r = 0.64; p < 0.001).

The p overall and p trend for the RS mutations were both highly significant (p<0.001) demonstrating a clear mutagenic effect, with the exception of the lowest dose tested (0.25 Gy) where no RS mutations were observed.

lncScores remained highly significant in both training and validation sets by multivariable regression (validation HR for DFS and OS, 2.19 and 2.83, respectively; both P < .001; Data Supplement).

In the G groups, a clear trend was observed where median speed followed the order Trt − < Trt + < Ctrl (Tobs = 2197, permutation p = 0.001, Holm-adjusted p = 0.004).

Univariate analyses revealed a highly significant association between ID/anaemia and the use of iron supplements ( p < 0.001) whereas none of the other associations tested between sociodemographic factors and iron supplementation were significant.

The corrected R 2 = 0.019 was small but highly significant ( p < 0.001).

The difference between their pain reduction was highly significant ( P <0.001).

According to the resultant results of joinpoint regression ( Figure 1 ), overall a notable reduction in HFRS morbidity was seen, with AAPC=−6.767 (95% CIs: −10.592 to −2.778; t=−3.278, p =0.001), and yet different stages had different variation trends: a decreasing trend during 1995–2004, with APC=−8.964 (95% CIs: −11.667 to −6.179; t=−6.547, p <0.001); during 2004–2008, with APC=−37.153 (95% CIs: −37.153 to 3.279; t=−1.828, p =0.084); during 2008–2020, with APC=−0.349 (95% CIs: −3.992 to 3.431; t=−0.197, p =0.846), and it seemed to show a cyclical fluctuation with 3–5 years since 2008.

This difference was highly significant in all of the subgroups ( p < 0.001) ( Table 1 and Table S3 ).

Age remains a highly significant predictor for hypertension (OR = 1.83, p < 0.001), while gender exhibits a minor protective effect for females compared to males, although this association does not reach statistical significance (OR = 0.96, p = 0.063).

Highly significant inhibition (p<0.001) was also observed for phenethylamine (41 ± 1%), tyramine (40 ± 5%), gramine (30 ± 4%) and serotonin 23 ± 3%), but the extent of inhibition was less than 50%, suggesting relatively low affinity interactions.

Differences between groups of *p < 0.05 were considered statistically significant, **p < 0.01 were considered highly significant, and ***p < 0.001 were considered very highly significant. 3 Results 3.1 Preparation and physicochemical characterization of the SIS/PDA/Cu bio-patch The preparation and surface modifications were illustrated in Fig. 1 a.

Relative expression peaked at day 2, exhibiting a highly significant upregulation ( p < 0.001).

In contrast, highly significant correlations were found between MNSIQ scores and corneal nerve fiber parameters, including the CNFD, CNBD, and CNFL, in both the paracentral (all p < 0.001) and inferior-whorl regions ( p < 0.01, p < 0.05, and p < 0.01, respectively).

As shown in Figure 3 A, reduction in the cell migration of GPE-treated DU145 cells was highly significant ( p < 0.001) in a dose-dependent manner, compared to control vehicle-treated cells.

Secular trend of KD incidence The KD incidence of subjects younger than 18 years significantly increased from 11.78 per 100,000 person-years in 2001 to 22.40 per 100,000 person-years in 2020 (AAPC = 5.4%, p < 0.001, Table 1 ), and 97.1% of KD patients were aged 0–5 years, which also demonstrated an increasing trend with an AAPC of 4.2% ( p < 0.001, Table 1 ; Fig. 1 a).

In addition, a comparison of all pairwise F ST values among the 52 populations showed a highly significant correlation among the F ST values calculated based on the 41-AIM panel and the 31-AIM panel (Mantel test, r = 0.987, p < 0.001), further indicating no significant loss of power to discern global ancestry in the smaller panel.

As the test for heterogeneity was highly significant ( P <0.001), we also applied a random-effect model in calculating the HR, which was 1.39 (95% CI: 0.97–1.99) ( Figure 1 ).

There were clear variations in pelt weights between ages and age–sex interactions, with highly significant differences ( p < 0.001) ( Table 3 ).

The spatial smooth term was highly significant (edf = 19.5, F = 8.9, p < 0.001), fully resolving residual spatial autocorrelation (post-hoc Moran’s I = -0.12, p = 0.96).

Globally, they show highly significant effects of experimental condition for each of the four dependent variables: general satisfaction [ F (4, 270) = 33.87, p < 0.001, η2 = 0.314], behavior satisfaction [ F (3, 253) = 35.50, p < 0.001, η2 = 0.324], the drop-out measure [ F (4, 270) = 29.27, p < 0.001, η2 = 0.283] and the behavioral measure “money” [ F (4, 257) = 28.46, p < 0.01, η2 = 0.278].

In contrast, a highly significant association was identified between preoperative skin marking and procedural success (P < 0.001).

No fast-food consumption was highly significant in decreasing the severity of PMS symptoms (OR 0.101, 95% CI (0.028–0.368), P = 0.001), healthy body weight was significantly associated with less severe symptoms of PMS (OR 0.231, 95% CI (0.070–0.782), P = 0.016), and more consumption of fruits was significantly associated with less severe PMS symptoms ( Table 4 ).

In males, risk association was seen for both the heterozygous and the mutant genotypes, with OR=2.683, 95% CI=1.193-6.034 and p=0.017 and OR=5.902, 95% CI=2.628-13.255 and p < 0.001 respectively, whereas for females, only the mutant GG genotype revealed risk association, with OR=9.248, 95% CI=2.666-32.077 and a highly significant p < 0.001.

The extended method using single cusp scoring (EM-S and EM(R)-S) had higher intra-species resolution, with highly significant differences in both cusp and tooth positions between D. bicornis, R. unicornis and C. simum (LME: p <0.001) ( Table 2 ).