Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
Eight energy metabolism pathways (oxidative phosphorylation, citrate cycle, glycolysis/gluconeogenesis, pyruvate metabolism, pentose phosphate pathway, butanoate or propanoate metabolism, synthesis and degradation of ketone bodies, and fatty acid metabolism) and four amino acid metabolism pathways (arginine and proline, phenylalanine, tryptophan, and the aliphatic amino acids valine, leucine and isoleucine metabolisms) were identified, most of them at the three stages and highly significant ( p < 0.001; Table 2 ).
highly significantP < 0.0010.0× alphaqualifiedgold
All differences among and between groups were classified according to the P -value levels: P < 0.05 was considered statistically significant; P < 0.01 indicated a highly significant difference; P < 0.001 represented an extremely significant difference; and P < 0.0001 signified a very extremely significant difference.
highly significantP < 0.0010.0× alphaqualifiedgold
All SCAF fractions (except for SCAF4 (high ionic strength and between 10 and 100 kDa; P < 0.01)) elicited highly significant ( P < 0.001) lymphoproliferative responses at the highest concentration (100 μg/ml) with a mean 13.2% (+/− 1.4 SD) increase observed across treatments compared with the negative control (Fig. 2 A).
highly significantP < .0010.0× alphaqualifiedgold
5 F) in a highly significant manner ( P < .001, Fig. 5 H). 2.4 Mitochondrial markers of apoptosis The level of pro-apoptotic Bax and the anti-apoptotic Bcl2 markers were measured in the hippocampus 10 days after Aβ 25–35 peptide oligomer i.c.v. injection in mice, by enzyme linked immunosorbent assay.
highly significantp < 0.0010.0× alphaqualifiedgold
It was found that the direct effect of exercise self-efficacy on depression increased progressively from low to high levels of perceived social support: from non-significant (β = 0.016, SE = 0.069, 95% CI = [−0.119, 0.151], p = 0.815), to significant (β = −0.109, SE = 0.053, 95% CI = [−0.214, −0.005], p < 0.05), to highly significant (β = −0.234, SE = 0.067, 95% CI = [−0.365, −0.104], p < 0.001).