Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
We additionally noted that the difference between the annotated numbers of AMGs and the expected frequencies of AMGs (calculated based on the proportion of genes of each category in the reference databases) (Additional file 2: Table S12) was statistically highly significant (chi-square p < 0.001).
highly significantp < 0.0010.0× alphaqualifiedgold
The progressive nature of the IOP reduction was confirmed by a linear mixed-effects model with a random intercept for patient (n = 232 observations from 29 patient clusters): all time main effects were highly significant (Day 30 vs. baseline β = −6.12, 95% CI −6.93 to −5.30, p < 0.001; Day 90 β = −7.56, 95% CI −8.37 to −6.74, p < 0.001; Day 180 β = −8.56, 95% CI −9.37 to −7.74, p < 0.001).
highly significantp values <0.0010.0× alphaqualifiedgold
These differences are robust across different age comparisons, with particularly strong effects observed in the transitions to ages 14 and 15, where the decrease in overlap compared to earlier ages consistently shows large effect sizes [HLe’s >3.0 (lower 95% CI >2.5)] and highly significant differences [all MWU p values <0.001].
highly significantp = 0.0010.0× alphaqualifiedgold
The combination of moderate inter-rater agreement with highly significant group-level performance (mean accuracy 76.12%, p = 0.001) indicates that discriminative information is objectively present in the sonifications (as validated in Section 3.4 ) and perceptually accessible to human listeners, but that exploiting this information requires perceptual acuity that varies across individuals.
highly significantp < 0.0010.0× alphaqualifiedgold
On the second day after a 10-day session of electric shocks in Context 1, the context conditioning was observed as a highly significant difference of behavioral response amplitudes in two contexts in all groups (panel “after learning”, Figure 3B , p < 0.001 for all groups, Wilcoxon Signed Rank Test, z = 3.6 for G1, z = 3.9 for G2, z = 3.5 for G3).