Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
MANOVA statistical analysis revealed a highly significant overall association between heavy metal profiles and pathohistological categories (Wilks’ Lambda = 0.038, F(36,316.52) = 12.177, p < 0.001), demonstrating that elemental accumulation patterns varied distinctively across tissue categories.
highly significantP<0.0010.0× alphaqualifiedgold
Notably, the direct effect of smoking decreased from 0.582 to 0.364 after accounting for mediators, yet remained highly significant (P<0.001), indicating that 62.5% of smoking’s impact operates through pathways not captured by these three mediators—presumably including direct epithelial toxicity, oxidative stress, protease-antiprotease imbalance, and immune dysregulation.
highly significantp<0.0010.0× alphaqualifiedgold
The between-group difference was highly significant (Figure 9 ; p<0.001), with the magnitude of improvement in the test group approximately seven times greater than that of the control group (Figure 10 ) Bleeding Index Day 14 At Day 14, both groups demonstrated statistically significant reductions in BI from baseline (Figure 11 ).
highly significantP < 0.0010.0× alphaqualifiedgold
The difference in mean VAS scores between the two groups was highly significant (P < 0.001), clearly establishing the superiority of the intraoperative local anesthetic cocktail administered in Group-A over regional anesthesia alone in Group-B for immediate post-operative pain control following knee arthroscopy.
highly significantp = 0.0010.0× alphaqualifiedgold
However, using one-way ANOVA multiple comparisons, the correlation of MAO-A levels to Aβ plaque levels was highly significant ([ 18 F]FAZIN3 versus [ 18 F]flotaza, p = 0.001 and [ 18 F]FAZIN3 versus [ 125 I]IBETA, p = 0.01), whereas [ 18 F]FAZIN3 versus [ 125 I]IPPI and [ 18 F]FEPPA were not significant.
highly significantp<0.0010.0× alphaqualifiedgold
conducted a large safety database review and found a highly significant increase in the incidence of myocarditis in combination nivolumab and ipilimumab therapy versus nivolumab monotherapy (0.27% vs. 0.06%; p<0.001; 5 fatal events vs. 1) ( 40 ).
Cardiovascular disease and lung cancer.
Front Oncol · 2024 · PMC10896114