Barely Significant

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highly significantP <0.010.2× alphaqualifiedgold
In paired samples, telomere shortening was observed in both sets of patients with HCC, who had either pre-existing serologically confirmed either hepatitis B or hepatitis C infection, but not in HCC patients without pre-existing HBV or HCV infection (mean ± S.E.M., 0.82 ± 0.02 (control), 0.81 ± 0.01 (HCC without HBV or HCV infection), 0.47 ± 0.01 (HCC + HBV), and 0.43 ± 0.01 (HCC_HCV), SS3.15, MS 1.58, F 195.29, P <0.001, ANOVA; between groups comparison, M1 or M4 compared with M2 and M1 or M4 compared with M3, but not M1 compared with M4, were highly significant, P <0.01, Tukey’s HSD test) ( Figure 1 A).
highly significantp < 0.010.2× alphaqualifiedgold
When these variables are included in the model they have (as a group) highly significant independent effect, apart from radiation exposure, on all circulatory disease, IHD and heart disease apart from IHD and hypertensive disease ( p < 0.01, results not shown); the adjusted trends with dose are very similar to those of the main analysis ( Table 3 , Supplementary Table S4 ).