Excerpts

All components of variance were highly significant (P<1×10 −5 ).

Replication cohort genotyping, QC and association analysis SNPs determined to have a nominally significant association with a nevirapine hypersensitivity phenotype ( P < 1 × 10 − 5 ) in the discovery cohort were subsequently typed in the replication cohort using either the Sequenom MassArray iPLEX platform (Sequenom Inc., San Diego, CA, USA) or custom TaqMan real-time PCR SNP genotyping assays (Life Technologies, Paisley, UK) according to the manufacturer’s protocols.

Association study Supplemental Figure s1 illustrates a highly significant correlation ( P = 0.001%) between grain filling rate and heat susceptibility index with grain yield.

Our meta-analysis found a highly significant difference between the two groups (MD = −0.95, 95% CI, [−1.27–0.64], P < 0.00001, Fig. 6 ).

Finally, we tested our key predictive variable (ACE count with and without AAA support) against five different individual or combined dependent variables (Table 2 ) with, in each case, the overall contribution of the variable being highly significant at P <0.00001.

This represents a highly significant association between in planta induced putative effectors and H3K27me3 domains (χ 2 = 45.217, p < 0.00001, S8 Table ).

Correlative analysis between the overlap score of Kgp and RgpB conducted on the pooled control and PD cohorts revealed a strong and highly significant correlation (Fig. 1k ; r = 0.864, p < 0.00001).

The comparison between PSADT and the primary PSA level also revealed highly significant differences (p < 0.00001).

Four SNPs showed associations with post-RT pain at the marginal significance level of p < 1 × 10 −5 ; rs16970540 in ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ( RFFL) or near to DNA ligase 3 ( LIG3 ) gene ( p = 1.7 × 10 −6 ), rs4584690, and rs7335912 in ATP-binding cassette, sub-family A, member 4 ( ABCC4)/ multidrug resistance protein 4 (MRP4) gene ( p = 5.5 × 10 −6 and p = 7.8 × 10 −6 , respectively), and rs73633565 in epidermal growth factor-like protein 6 ( EGFL6 ) gene ( p = 8.1 × 10 −6 ).

However, for minor bleeding, there was a nonsignificant effect of NOACs on reducing the risk of bleeding (OR = 0.72, 95% CI = 0.47–1.09; p = 0.12), which became highly significant in favor of NOACs after sensitivity analysis (OR = 0.55, 95% CI = 0.49–0.61]; p < 0.00001).

The correlation between PSA levels and AMACR/p504s expression was found to be highly significant, with positive AMACR/p504s expression correlating with higher PSA levels ( P < 0.00001).

In terms of knowledge regarding flossing, 88% dental and 64% medical students had heard about flossing, and the difference was highly significant ( P =0.00001).

An analysis of IBD between individuals for the full dataset was highly significant ( p < 0.00001).

The differences were found to be highly significant ( t -test, p < 0.00001).

Correlation of CDX2 with clinicopathological parameters CDX2 expression was inversely associated with lymph node metastasis (high CDX2 expression was associated with decreased lymph node metastasis (RR=1.52, 95% CI: 1.29-1.79, P<0.00001) ( Figure 5 ) however, CDX2 expression was significantly higher in poorly differentiated gastric cancers (RR=1.52, 1.52; and significantly higher in well-differentiated and latent gastric cancers marginal significance compared with 95% CI: 1.22-1.87, P<0.00001) ( Figure 6 ) was observed (RR =0.82, 95%).CI =0.67-1.01, P=0.07) ( Figure 8 ).

These models showed that indeed there are highly significant differences ( p < 0.00001) in infection rates between some populations for all three pathogens tested ( Data S2 ).

The list of nominally significant CpGs ( p < 1 × 10 −5 ) sorted by their p-value for low and high audiometric frequencies are depicted.

Analysis of the microarray data revealed that there was indeed a single, highly significant ( p < 10 −5 ) chromosomal cluster of genes negatively regulated by VHL-1 in a HIF-1–independent manner and that in total this cluster extended over 110 kb to include F56A4.9, Y45G12C.9, Y45G12C.12, and Y45G12C.2 in addition to the six genes validated by RNase protection assay.

Heterogeneity was negligible (I 2 = 0%), and the test for overall effect was highly significant (Z = 6.16, p < 0.00001) ( Figure 2 ). 3.10.

The mean synonymous site nucleotide diversity ( π syn ) for X-linked genes (Tables 1 and 2 ; Additional file 1 : Table S4) is 0.00017, versus 0.0018 for all autosomal genes identified; the mean estimated nucleotide diversity for all sites ( π ) is 0.00038 for the X-linked region, again much lower than values for the autosomal region or PAR (0.0017 and 0.0020, respectively, which do not differ significantly (Wilcoxon rank sum P = 0.12), while the difference from the X-linked region is highly significant ( P < 1 × 10 −5 ) for both regions).

Across these 154 cells, we found a modest but highly significant decrease in the median linear–circular correlation rho statistic (0.46 vs 0.41, P < 1 × 10 −5 , Z s.r. = 4.78, n = 154; Figure 6 a).

Although highly significant ( p < 0.00001), the result indicates that the assessment of alertness may be quite variable.

This difference between groups at recruitment was highly significant (Kruskal–Wallis test, χ 2 (2) = 25.2; p < 10 −5 ), and represents a failure of randomisation due to our limited sampling.

A highly significant ( p ≤ 0.00001) reduction of E‐cadherin expression was observed in the order of HPV16+ < HPV18+ < HPV16+/18+ in both cell models.

Lower HR after repeated performances The Friedman Test for changes in HR, including baseline (a 1 min run of hopping on the spot) and the three live performances, revealed highly significant changes ( p = 0.00001).