Excerpts

The FLA demonstrated the shortest mean duration (10.88 ± 1.2 min), with a highly significant difference (analysis of variance F-test, P < 0.00001) compared to the eyebrow, bifrontal trans-basal, and pterional approaches.

The overall effect was highly significant (Z=4.90, P<0.00001), confirming the effect of supply center management protocols on reducing the incidence of HAIs.

The pooled HR remained highly significant (HR = 0.56, 95% CI 0.45–0.70; P < 0.00001) ( Supplementary Figure 1A ). 3.3.2.

The STRING (Search Tool for the Retrieval of Interacting Genes/proteins) functional analysis of DAPs during the 8–12 cell-to-morula transition confirmed the highly significant enrichment in the ribosome, spliceosome and RNA transport pathways (p-values < 10 −5 ; see all enriched terms during the 8–12 cell-to-morula transition in Supplementary Table S5 ).

Four SNPs showed associations with post-RT pain at the marginal significance level of p < 1 × 10 −5 ; rs16970540 in ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ( RFFL) or near to DNA ligase 3 ( LIG3 ) gene ( p = 1.7 × 10 −6 ), rs4584690, and rs7335912 in ATP-binding cassette, sub-family A, member 4 ( ABCC4)/ multidrug resistance protein 4 (MRP4) gene ( p = 5.5 × 10 −6 and p = 7.8 × 10 −6 , respectively), and rs73633565 in epidermal growth factor-like protein 6 ( EGFL6 ) gene ( p = 8.1 × 10 −6 ).

A test for subgroup differences revealed a highly significant difference between the SLT and DLT subgroups (Chi 2 = 749.98, p < 0.00001), further supporting the idea that the effects of thermal softening may differ based on tube type.

Indeed, four, highly significant (pairwise homoplasy index test, P < 0.00001) signals of recombination have been revealed at coordinates closely corresponding to the divergent regions.

A genome-wide association study (GWAS) screened 297,876 SNPs and identified highly significant associations ( p < 1 × 10 −5 ) with head smut resistance in sorghum.

The regression model for PHA production was highly significant with p -values < 0.001%.

The highly significant similarity of gene expression from same-host papillomas suggested that germline polymorphisms affect constitutive levels of gene expression in benign tumors ( P < 0.00001 by permutation; see Materials and methods).

Regarding the percent inhibition of paw edema, the main effects of the treatment and time factors were highly significant by the four solutions used ( P <0.00001), and their interaction was also significant ( P =0.006, 0.006, 0.0062, and 0.0058 for Manly’s approach, Edgington’s approach, Still and White’s permutation of residuals and ter Braak’ methods, respectively).

The correlation was 97.1% (67/69 cases), which was highly significant (Chi-square test, p < 0.00001).

LR was observed in 80% of patients with postoperative AL (4/5) while only 9% of patients without AL (12/130); the difference was highly significant (p = 0.00001).

Using multivariate analysis of variance (MANOVA), the difference in the consumption frequencies of the items was highly significant ( p -value = 0.00001).

Figure 4 also implies that the association between the BIMD 2015 and SIR/SMR is strongly fluctuating over time (tests on time x BIMD interaction are highly significant with p < 0.00001).

The LSL model ( Table 1 ) returned highly significant effects ( p < 0.00001) for both ES Yield and Yield Control .

These changes correspond to a highly significant ( t (44) = 5.10, p < 0.00001) decrease in average FA in the white matter between left thalamus and left IPL (Figure 2B ).

All correlation coefficients between these two datasets were above 0.99 (Pearson’s r ) and highly significant with p < 1e-5.

Although both effect sizes of PM 2.5 and PM 10 in the fully adjusted models were small (β-value of PM 2.5 = − 0.032; β-value of PM 10 = − 0.039, respectively), they were highly significant ( P -value < 0.00001).

Gender exhibited a highly significant association (X2 = 45.9, p < 0.00001), highlighting differences in awareness levels between males and females; women are more knowledgeable than men.

The chromatic differences between guppies and backgrounds (ΔS) are all highly significant ( p < 0.00001) for both light environments ( FS and OC , Table 3 and Figure S12 ), with ΔS >>1 ( Table 3 and Figure S11 ), indicating strong chromatic contrast between guppies and both spacelight and substrates.

The strongest structure was among all populations (F ST = 0.098), followed by differentiation among the two ecotypes (F CT = 0.068) and then differentiation among populations within ecotypes (F SC = 0.032), and all were highly significant (p < 10 −5 , Table 5 ).

The ICI and WI showed a strong and highly significant correlation (r = 0.53141, p < 0.00001).

Hence, we detected a highly significant ( P < 0.00001, Fisher's exact test) correlation between trees homozygous for the acro ‐SNP and the early cone‐setting phenotype.

In addition, disease duration correlated highly significant (p<0.00001) with the mean longitudinal FA changes in all tract systems.