Excerpts

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

In particular, the fluorescence intensity of SUVs preferred by 15GALA-NP increased approximately 2 orders of magnitude compared to free GALA, showing highly significant skewness ( p = 1.12 –141) by comparing the two distributions in a two-sided Welch’s t -test.

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

Of these, 140 SNPs indexed differences in HDL- and LDL-cholesterol, triglycerides, C-reactive protein, fibrinogen, factor VII, apolipoproteins AI and B, lipoprotein-associated phospholipase A2, homocysteine or folate, some with large effect sizes and highly significant P -values (e.g. 2.15 standard deviations at P = 9.2 × 10 −140 for F7 rs6046 and FVII levels).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

This overlap is highly significant by factor of over-representation (4) and P -value ( P < 3.1 e-136).

Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10 -136 ) in a cohort of more than 2300 Lagotto Romagnolo dogs.

Comparison of F ST values on chromosome 1 between PK10 and Thailand were highly significant (pairwise- t = 26.9, d.f. = 1934, p -value = 1.15 × 10 −135 ), and PK10 F ST values were greater than Thailand F ST values in 1387 of the 1935 genes compared (71.6%).

Figure 7B shows there was a highly significant overlap between the genes affected by cordycepin in the two cell lines ( P < 1.44 × 10 −135 by one‐tailed Fisher's exact test).

Furthermore, the Z-score-based meta-analysis of 1,239 animals in the exploratory cohort revealed a highly significant negative correlation between pH and lactate levels at the individual animal level ( r =–0.62, P =7.54 × 10 –135 ; Figure 1B ).

The yield difference between the two basins was highly significant (t = 46.11, p < 10− 133 , Cohen’s d = -2.77), confirming the stark separation of performance states.

In fact, the correlation between hearing and deaf regional thickness measurements was highly significant (p = 6.85 × 10 −132 ), demonstrating an R 2 value of 0.98.

This highly significant 3-way overlap (hypergeometric test, P ≈ 5 × 10 –131 ) indicated a conserved set of p63-bound regulatory regions across luminal and basal contexts.

Especially, VIT_00s0324g00050 showed highly significant differential expression ( P = 3.79E-129). qRT-PCR analysis To confirm the results obtained from RNA-seq, relative expression profiles of 30 genes were analyzed by real-time RT-PCR at the three fruit developmental stages in black and white spine grapes.

For KEGG GSs, there was a large number of highly significant GS associations (minimum nominal p = 3.84x10 −129 ); however, the majority of the top results were driven by the 13 GSs which include the human leukocyte antigen (HLA) genes.

Changes to plan shape Throughout the entire handaxe sample, the correlation between tip length and PC1 ( Fig 14 ) is highly significant (r = .642, p = 1.2889E-128), supporting an allometric relationship between handaxe shape and size.

In our sample, the correlation between FA and MD values was highly significant (whole-brain average r (FA,MD) =−0.75, P =9.9e–128).

The correlation between total viral genome copies and sub-genomic E gene copies was highly significant ( p = 3.81 × 10 −127 ), but a high level of variance was observed between live viral titres measured by focus forming assay and both total and sub-genomic RNA titres ( Figure 4 a).

Compared to size-matched random genomic regions, K122Q-bound enhancers showed highly significant enrichment of the canonical CRE motif (Fold Enrichment=13.7, P =1.0 × 10 -125 ), with 42.5% of enhancers containing the motif versus 3.1% of background regions ( Supplementary Fig. 2 ).

We found a highly significant association (P = 1.0×10 −124 ) of the risk allele at the LIPA locus with LIPA mRNA levels in these cells explaining ∼50% of the variance in the expression of the gene ( Figure 6 ).There were no other highly significant associations between CAD risk alleles and gene expression at the novel loci ( Table S7a and S7b ).

[ 19 ], 244 were significantly positively correlated to YAP1 expression in the GSE45547 expression dataset, demonstrating a highly significant enrichment ( Figure 6 B; Hypergeometric test, p = 1.961398 × 10 −122 ).

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

This enrichment was highly significant ( P = 2.35 × 10 −121 ) with an odds ratio of 12.90, indicating that outlier SVs were nearly 13 times more likely to occur within regions of elevated genetic differentiation based on SNPs.

Comparison of Scrib module and PcG mutant RNA-Seq datasets revealed that nearly half of the genes upregulated upon polarity loss are also upregulated in PcG mutant tissues, a highly significant enrichment (p < 6.98e-121, Figure 6C ).

1c and 1d ) is highly significant ( χ 2 test-statistic = 548.68; d.f. = 2; N = 1,913; P = 7.2 × 10 −120 ).