Excerpts

Changes to plan shape Throughout the entire handaxe sample, the correlation between tip length and PC1 ( Fig 14 ) is highly significant (r = .642, p = 1.2889E-128), supporting an allometric relationship between handaxe shape and size.

In our sample, the correlation between FA and MD values was highly significant (whole-brain average r (FA,MD) =−0.75, P =9.9e–128).

The correlation between total viral genome copies and sub-genomic E gene copies was highly significant ( p = 3.81 × 10 −127 ), but a high level of variance was observed between live viral titres measured by focus forming assay and both total and sub-genomic RNA titres ( Figure 4 a).

Compared to size-matched random genomic regions, K122Q-bound enhancers showed highly significant enrichment of the canonical CRE motif (Fold Enrichment=13.7, P =1.0 × 10 -125 ), with 42.5% of enhancers containing the motif versus 3.1% of background regions ( Supplementary Fig. 2 ).

We found a highly significant association (P = 1.0×10 −124 ) of the risk allele at the LIPA locus with LIPA mRNA levels in these cells explaining ∼50% of the variance in the expression of the gene ( Figure 6 ).There were no other highly significant associations between CAD risk alleles and gene expression at the novel loci ( Table S7a and S7b ).

[ 19 ], 244 were significantly positively correlated to YAP1 expression in the GSE45547 expression dataset, demonstrating a highly significant enrichment ( Figure 6 B; Hypergeometric test, p = 1.961398 × 10 −122 ).

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

This enrichment was highly significant ( P = 2.35 × 10 −121 ) with an odds ratio of 12.90, indicating that outlier SVs were nearly 13 times more likely to occur within regions of elevated genetic differentiation based on SNPs.

Comparison of Scrib module and PcG mutant RNA-Seq datasets revealed that nearly half of the genes upregulated upon polarity loss are also upregulated in PcG mutant tissues, a highly significant enrichment (p < 6.98e-121, Figure 6C ).

1c and 1d ) is highly significant ( χ 2 test-statistic = 548.68; d.f. = 2; N = 1,913; P = 7.2 × 10 −120 ).

Statistical analysis showed that there was a strong and highly significant negative correlation between the rate of change in expression and chimeric frequency (Pearson: r = −0.556, p = 4.69 × 10 −119 ; Spearman: r = −0.601, p = 7.34 × 10 −144 ).

The CytoTRACE score showed a weak but highly significant negative correlation with latent time (Spearman ρ = −0.25, p = 1.9 × 10 −118 ), indicating that, although capturing distinct facets of the transcriptome, the two orthogonal approaches suggested on a common developmental trajectory from mesophyll precursors toward terminally differentiated guard cells ( Tables S1 and S2 ). 3.2.

In particular, highly significant genome-wide associations signals were observed in the coding region of the translocase of the mitochondrial outer membrane gene (TOMM40: rs2075650, p = 8.54×10 −116 , OR = 4.48; rs157580, p = 9.6×10 −35 , OR = 0.51 and rs8106922, p = 1.17×10 −25 , OR = 0.57), upstream of the apolipoprotein C-I gene (APOC1: rs439401, p = 8.82×10 −29 , OR = 0.54), inside the poliovirus receptor related 2 isoform delta gene (PVRL2: rs6859, p = 7.87×10 −28 , OR = 1.7 and rs3852861 p = 5.32×10 −11 , OR = 0.64) and between TOMM40 and the APOE gene (rs405509, p = 2.29×10 −27 , OR = 0.57).

Nucleotides For the class of nucleotides, urate showed a highly significant difference with higher concentrations in males (p = 7.04 × 10 −114 ).

Although we cannot rule out the possibility that widespread shallow oscillations persisted, a comparison between the same genes in Ctrl and SCNx groups showed a dramatic and highly significant (Wilcoxon signed-rank test, P = 8 × 10 − 114 ) decrease in amplitude after SCN lesion (Fig. 1 L, left).

What the reviewer fails to mention is that because 32% of genes do change orientation and given a sample size that will make expectations highly significant, the null hypothesis of no change will be rejected by a more significant P value (P = 10 -113 ) by Fisher test, therefore rejecting the WGD model .

Consistent with observations that YY1 is a cofactor of CTCF for X-chromosome inactivation ( 73 ), there is a highly significant overlap between boundaries bound by CTCF and YY1 ( n = 534; P ≤ 10 −113 hypergeometric test) suggesting the possibility of synergistic action between these two factors.

P values were highly significant ( P <1 × 10 −112 ).

The coefficient of linear correlation between the input and output signals was r = 0.9421, and it was highly significant ( p = 1.46 × 10 –111 ).

Meta-analyses of cis -eQTLs for brain-related traits show at least one variant in the ANKDD1B gene to be highly significant in the cortex ( P = 3.18×10 -110 ; Table F in S1 Table ) and nominally significant in the hippocampus ( P =.003; Table G in S1 Table ) [ 26 ].

Therefore, we calculated the statistical probabilities of two-way overlap between exosome and CP190, BEAF-32 or CTCF sites by hypergeometric tests considering only active TSSs of all annotated gene isoforms and indeed observed highly significant overlap over expectation ( P < 3.7 × 10 − 110 for each comparison).

Since the A and flanking C1 and C2 exons constitute only a small portion of the coding genome (∼10 million nucleotides as per our dataset), this enrichment is highly significant as revealed by a Chi-square test (P<1.99e-108), when comparing the ratios of driver vs. passenger mutations in alternative splicing neighborhoods as compared to the rest of the exome.

As anticipated, lipid ratios capturing PUFA synthesis, namely PE(P-16:0_18:2)/PE(P-16:0_20:4), PE(P-18:0_18:2)/PE(P-18:0_20:4), PE(P-16:0_18:3)/PE(P-16:0_20:5) and PE(P-18:0_18:3)/PE(P-18:0_20:5), exhibited highly significant associations with FADS1/FADS2/FADS3 loci [575 SNPs; top hit: rs174564 for the PE(P-18:0/18:2)/PE(P-18:0/20:4); imputation r 2 = 0.999; beta = 0.49; p-value = 8.07 × 10 −107 ; p-gain = 2.60 × 10 +83 ].

We found that 48% (237/489) of Hoxa2-regulated genes had at least one Hoxa2-bound region assigned to them, which represents a highly significant enrichment compared with all genes ( P = 1.1 e –106) ( Figure 4 A).

Bioinformatics analysis of training cohorts identified a 61-gene signature that was highly significantly associated with RFS (HR = 37.08, P = 2.68*10 −106 , sensitivity = 89.29%, specificity = 89.61%, and AUC = 0.937).