Excerpts

The variance of the random effect was highly significant in all these models (p<0.0001).

Highly significant improvements (p < 0.0001) were noted on all efficacy measures over the study period.

In addition, a highly significant association ( p <0.0001) was observed between weight gain and the number of cigarette-free days.

At 0–6 m, hippocampal loss in mild cognitive impairment and Alzheimer's disease was already highly significant ( P < 0.0001), whereas the loss in normal became significant in the 0–12 m interval only ( P = 0.005).

A Mantels test for matrix correspondence between pair-wise genetic ( D AS ) and geographic distance (km) revealed a highly significant positive correlation between these two measures (R XY = 0.394, p<0.0001, Figure 3 ).

The difference between the frail group and the others is highly significant [ p < 0.0001 by Mann–Whitney U -test (MWU)].

In this analysis, group differences in subjective pain scores were highly significant before controlling for the effect of anterior cingulate cortex activation ( F = 38.0, P <0.0001); a finding that was reversed ( F = 1.8, P = 0.195) when removing (regressing out) this effect.

Our measurements showed that MCF-10A had a small, yet highly significant, preference to grow on 2D conditions compared to control 3D ECMs (1.1 fold, with P < 0.0001) or tumor-associated 3D ECMs (1.3 fold, P < 0.0001).

Statistical analyses Microsatellite diversity, Hardy-Weinberg and genotypic linkage equilibrium GenePop 3.4 [ 14 ] was initially employed to screen for deviations from Hardy-Weinberg (H-W) equilibrium and two loci (BFRO4 and ONE2) were excluded due to highly significant heterozygote deficiency (P < 0.0001) in several populations, likely indicating the presence of null alleles.

Similarly, all non-constant terms in a cubic regression of onset age on number of repeats were highly significant (p<0.0001), and the overall F-test for comparing the cubic model to a constant-age-of-onset model had a p-value of 4.4e-15.

For women, only patients <65 years showed a decreasing trend (β = −32.3, P < 0.0001).

The correlation between CXR results at autopsy and gross lung PA scores as calculated by non-parametric Spearman's rho (Rs) was strong (Rs = 0.75) and highly significant (p<0.0001) ( Figure 4A ).

Because of the large number of residues examined, the differences in the means between conserved and non-conserved structures are highly significant (p < 0.0001).

For weight gain over the entire period from the second trimester to 18 months, PPAR γ 2 Pro12Pro carriers had a significantly lower growth rate for weight than the other genotypes, and there was a significant trend for each additional Ala12 allele ( P < 0.0001).

By performing immunofluorescence (IF) staining of ZRANB1 (green) and MDA (magenta) in the KIRC tissue microarrays, we found a highly significant positive correlation (R2 = 0.47, P < 0.0001) between ZRANB1 and MDA ( Fig. 1, F and G ).

The differences where highly significant in the Wilcoxon test (z = -3,79; p < 0,0001).

A t -test for correlated samples confirmed a highly significant mean decrease of 37.77 points ( P < 0.0001).

The ability for these two themes to distinguish two groups within the data was further supported by the nonparametric multivariate inference test as it indicated a highly significant difference between those coding units coded with either theme (ANOVA test statistic = 13, df = 8, df2 = 927, p < 0.0001).

In fact, it was observed a highly significant (p < 0.0001) difference between the controls and MM or between MGUS and MM, while no significance was found between controls and MGUS groups (p = 0.95) by means of a two by two comparison of the three groups (controls, MGUS and MM) concerning the distribution of K- ras gene mutation, Interestingly, significant increases (P = 0.02) of serum bFGF levels were observed in patients showing K- ras gene mutation (median = 4.6 pg/ml; range = 1.2–19.6 pg/ml) as compared with those in which the gene was in the wild type form (median = 2.2 pg/ml; range = 1.0–20.8 pg/ml).

The model F-values were found to be highly significant for both responses (vesicle size and entrapment efficiency), with p-values < 0.0001 for vesicle size and 0.0014 for entrapment efficiency.

KCNA6 and HCN2 showed highly significant differences (**** p < 0.0001), while KCNC1 and SCN1A also demonstrated significant downregulation (* p < 0.05).

These effects were highly significant after adjustment for multiple comparisons (p<0.0001, Table S2 ).

For OC125, M11-like, and OC125-like, the differences between binding and non-binding were highly significant, with p < 0.0001 at 95% confidence. 3.3.

For human genes, highly significant differences were found between G1 and G2 (F = 1.29; p <0.0001), G1 and G3 (F = 1.33; p <0.0001), or G1 and G4 exons (F = 1.33; p <0.0001), while none was found between G2 and G3 (F = 1.04; p = 0.4254), G2 and G4 (F = 1.03; p = 0.4285), or G3 and G4 exons (F = 1.00; p = 0.9243).

The perindopril trials demonstrated a highly significant event reduction (OR 0.78; 95% CI: 0.72–0.85; p < 0.0001 (Fig. 4) .