Barely Significant

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highly significantP < 0.00010.0× alphaqualifiedgold
Analysis by R, fitting a GLM with a quasibinomial error structure, confirmed the highly significant main effects of age (change in deviance = 84.45, P < 0.0001, for 6 df) and region (change in deviance = 27.03, P < 0.0001, for 3 df), and the 2-way interaction between age and region (change in deviance = 34.85, P = 0.01, for 18 df, residual degrees of freedom = 1615).
extremely significantp < 0.00010.0× alphaqualified
Results There was an extremely significant (p < 0.0001) reduction in body weight (108.62 kg→ 94.48 kg), body mass index (36.46 kg/m 2 →31.76 kg/m 2 ), systolic blood pressure (125.71 mmHg→109.05 mmHg), diastolic blood pressure (84.52 mmHg→ 75.24 mmHg), total cholesterol (208.24 mg/dl→186.62 mg/dl), triacylglicerols (218.67 mg/dl→113.90 mg/dl) and glucose (109.81 mg/dl→ 93.33 mg/dl).
highly significantp < 0.00010.0× alphaqualifiedgold
did not reach statistical significancep = 0.091.8× alphaplainly factual
The association of duration of use remained highly significant for moderate or greater AR ( p < 0.0001) but the association with moderate or greater MR did not reach statistical significance ( p = 0.09, one-sided) while the trend for moderate or greater TR remained statistically significant ( p = 0.007, one-sided).
extremely significantp < 0.00010.0× alphaqualified
Post-facto calculation for this restricted TIR (rTIR), revealed extremely significant differences between the groups and across days (Two-way ANOVA, main effect, cohort: p < 0.0001; main effect, day: p < 0.0001, interaction cohort × day: p < 0.00001, Supplementary Fig.
extremely significantP < 0.00010.0× alphaqualified
P values are calculated using unpaired t tests with Welch’s correction, and the levels of statistical significance are assigned as follows: P ≥ 0.05, not significant (n.s.); 0.01 ≤ P < 0.05, significant (*); 0.001≤ P < 0.01, very significant (**); P 0.0001 ≤ P < 0.001, extremely significant (***); P < 0.0001, extremely significant (****).