Considering the RI analysis, discrimination between positive and negative samples was highly significant (p<0.0001).
Excerpts
The deviations between the torsional spaces covered are highly significant for almost all maps (p-value < 0.0001), with significantly higher mean distance-to-centroid for all MD maps (see also Additional file 1 : Table S4).
The median (IQR) growth rate of children pre- and post-tests were −4.0 (−5.4–−2.1) SDS and 0.1 (−1.9–1.4) SDS respectively, a difference highly significant ( p < 0.0001) (Fig. 3B ).
These differences were highly significant ( p < 0.0001).
A highly significant difference ( P < 0.0001) was observed in IL-4 production between Adj+pep 2nd and Peptide 2nd.
Twenty-four week-infected mice developed highly significant bone resorption relative to control mice in the maxilla palatal (0.65 v. 0.43 mm 2 ) ( P = 0.0001) and mandible lingual sides (0.80 v. 0.66 mm 2 ) ( P = 0.003) (Fig 1C and 1D ) of the jaw.
Ejection fraction was found to have a highly significant negative correlation with the development of in-hospital HF (p = .0001), while MPI was found to have a highly significant positive correlation (p = .0001).
No significant differences in the prognostic value are noted between iPET-2 and i-PET-4 with both showing highly significant differences in EFS between the CMR and nCMR patients ( P -value < 0.0001): patients with iPET-2-CMR and iPET-2-nCMR had 3-y-EFS’s of 93.1% and 45.5%, respectively while the respective values for patients with iPET-4-CMR and iPET-4-nCMR were 89.5 and 39.4%.
To ensure concordance between data generated in our MHRP laboratory and previously published CATNAP data, we performed a bridging analysis using 3 PSVs and 18 NAbs and observed a highly significant correlation between IC 50 endpoints ( S2 Fig , p<0.0001, r = 0.9043).
At 12 weeks, the investigators noted a highly significant difference in mean percentage change in tumour size between the study and control groups (–20% vs . +19%, P <0.0001).
Although there is considerable individual variation between prediction and soil data, the fit is highly significant [ p < 0.0001, as discussed in the Supplemental Material ( http://www.ehponline.org/docs/2006/8659/suppl.pdf )].
Patients with presence of vascular invasion also showed a significant trend toward worse overall survival ( Table 2 ; Figure 2C ) and recurrence-free survival ( Figure 2D ) compared to the patients with absence of vascular invasion ( P <0.0001).
Comparison of respiration rates at 5 to 35°C yielded also highly significant differences (two-tailed, unpaired t-test p<0.0001, DF = 23, t = 15.512).
Doxy-induction during differentiation led to a highly significant reduction of the relative amount of MAP2-positive neurons after 30 days in a dose-dependent manner (n = 3, Tukey's multiple comparisons test, p < 0.0001).
As shown in Figure 3 , this resulted in a highly significant increase in performance (bootstrap test resulting in p<0.0001 for all tested metrics).
Moreover, the effect of ON stimulation on the 1+ NC trial following the C–NC transition was markedly significant when compared to all other ON stimulation NC trials (χ 2 test, P = 0.0001).
Two-way ANOVA showed highly significant time-dependent block for all peptides compared to control ( p < 0.0001, F = 6.83, df = 9).
The vedolizumab group (n = 15) showed a significant increase ( P = 0.007) despite greater variability in baseline concentrations, while the anti-TNF group (n = 14) demonstrated a more uniform response pattern with highly significant increases ( P < 0.0001).
At t = 80 min, normalized transfer into the lymphatic region followed the ordering 10 kDa > 70 kDa > Bodipy FL C16 > 2000 kDa dextran, with overall differences across dyes highly significant ( P < 0.0001, Brown–Forsythe and Welch ANOVA with Dunnett's T3 multiple comparisons) ( Fig. 5D ).
This quantitative analysis revealed highly significant overall differences between groups and sample areas (Group: F (1,40) = 38.89; p < 0.0001; Area: F (3,40) = 7.9; p = 0.0003; Interaction: F (3,40) = 3.2; p = 0.0332).
8.5 for ICG; both p < 0.0001), an association that remained highly significant for IMP after controlling for ICG recommendations in a multivariate analysis (adjusted OR = 35.8, p < 0.0001 for IMP vs. 2.5, p = 0.066 for ICG).
Two-way ANOVA revealed highly significant genotype effects for TaExpA6 (p < 0.0001), with Bonferroni’s multiple comparisons test showing consistent and significant changes in mRNA levels at 10, 14, and 21 DAA (adjusted p-value < 0.05, Figure 6E ).
A highly significant correlation (r = 0.475, p <0.0001) was also found between the Ct values of the concordant positive saliva and NPS specimens.
The incidence rate showed a rapidly increasing trend from 1975 to 1987, with an APC of 3.3% (95% confidence interval [CI] = 2.8–3.9%, P < 0.0001), while this increase slowed from 1988 to 2001 (APC = 0.8%, 95% CI = 0.4–1.1%, P < 0.0001), and was followed by a decreasing trend from 2002 to 2016 (APC= −0.7%, 95% CI= −0.9% to −0.5%, P < 0.0001).
A Pearson’s correlation between the dynamic rate changes in the oximeter signals reveals a highly significant inverse correlation for phosphorescence changes ( r = −0.597; 95% confidence, −0.710 to −0.454; P < 0.0001) and a highly significant positive correlation for changes in pO 2 ( r = 0.594; 95% confidence, 0.451 to 0.707; P < 0.0001).