The increase of aversive behavior in response to the visual cue was highly significant in Mela(CTmGluR6)-treated ( p = 0.0003) and C57BL/6 mice ( p = 0.0026), but no behavioral change in response to the drifting stimulus was seen in untreated rd1 littermates ( p = 0.83, Fig. 7b ).
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Surgical resection was a highly significant factor reducing the risk of death by 74% ( P = 0.0003; hazard ratio 0.26, 95% C.I. 0.12 to 0.55).
Again, the correlation between total anti-spike IgG and neutralizing antibodies was highly significant (p=0.0003; Figure 4D ), suggesting that the decrease in the number of specific antibodies goes in hand with the reduction in their neutralizing ability.
Finally, a Mann-Whitney U test revealed a highly significant difference in the 3-month climatic trajectories between outbreak (n = 10) and non-outbreak months (n = 29) (U = 31.0, p = 0.0003).
The differences in damaged cells in patients were highly significant after the operation (p=0.0003).
The CD4+ T-cell count and sCD14 levels showed a highly significant negative correlation at BL (ρ = −0.42, p = 0.0003) ( Figure 4A ) and at w72 (ρ = −0.32, p = 0.007).
Consequently, the whole regression model was highly significant ( p = 0.0003) and had an explanation capability of 87.1% of the clinical outcomes.
Furthermore, an investigation of taVNS application in fatigue syndrome reported highly significant effects ( p < 0.0003) with a sample size of n = 15 [ 51 ].
After one week of SFOH intake, a highly significant increase in Fe(2+) and Fe(3+) was observed in the patients' stool supernatant (p = 0.0003 and p = 0.0085, respectively), which then decreased by week 4 (t2, V2, endpoint of the study), but was still significantly higher (p = 0.0028 and p = 0.0424) than at baseline t0 (Fig. 6 ).
The result also showed serum GOT, GPT and ALP in HFD groups it revealed that, no significant changes in serum GOT and GPT level accompanied with a very highly significant elevation in serum ALP as compared with negative control group (P> 0.0003).
A positive signal was detected in 11/14 samples, and only 1/14 among negative controls, with a highly significant statistical difference (p = 0.0003, Fisher’s exact test), based on a blind assessment by a naïve observer.
Group A showed a mean reduction in the ulcer area by 8.26 mm 2 ( 75.99%) which is highly significant ( P -value = 0.0003) [ Table 4 ].
The maximal response caused by 10 –4 mol/L resveratrol was extremely significant—83.49 ± 2.85% ( n = 10; p = 0.0003) of the contractions of the strips before resveratrol administration ( Figure 3 and Table 1 and Supplementary Table S1 ).
The comparison of the spectral counts in the inflammatory/immune category was highly significant ( Z = −3.16, P -value = 0.0003), while the comparison for all other proteins was not significant ( Z = 0.3602, P -value = 0.7206).
For the right adrenal gland, the difference between the study group (1.85 ± 0.05 g/m 2 ) and the control group (1.42 ± 0.24 g/m 2 ) was extremely significant (t-test, p = 0.0003, t = 3.75, df = 118).
When the evolutionary half-life is measured for the nine replicate populations, this evolutionary half-life difference compared to T9002 is highly significant (one-tailed t-test, p = 0.0003).
Among these, four genes showed high statistical significance ( G2E3, p = 0.0031, FC = 1.9; ZNF695 , p = 0.0096, FC = 2.0; CEP41 , p = 0.0023, FC = 2.2; RGPD1 , p = 0.0031, FC = 2.9), whereas the remaining six genes were highly significant ( NOL4, p = 0.0003, FC = 3.1; SOX6, p = 0.0003, FC = 3.2; GOLGA6C, p = 0.0002, FC = 5.9; PCDHA9, p = 0.0001, FC = 11; GOLGA6B , p = 0.0009, FC = 4.1; LMLN , p < 0.0001, FC = 3.4).
However, subsequent subgroup analysis demonstrated a significant trend toward an increment in MLD (MD = −0.25 mm, 95 CI −0.38 to −0.11 mm, p = 0.0003; I 2 = 0%, p = 0.70, Figure 2A ) was observed in the everolimus-eluting stents (EES) group.
At the 12-month follow-up, the difference was highly significant, with an OR of 15.51 (95% CI: 3.57–67.36); p = 0.0003 for four studies [ 5 , 17 , 18 , 20 ] strongly favoring the inverted ILM flap method for anatomical closure.
Correlation of absolute against normalized hormone concentrations was highly significant for both cortisol and melatonin (cortisol: Pearson’s r = 0.8238, p = 0.0003; melatonin: Pearson’s r = 0.7564, p = 0.0001).
In group G4, the improvement was more pronounced and also highly significant ( p = 0.0003).
vivax attacks shows a highly significant positive correlation with maximum or overall P. falciparum parasitemia (R = 0.12 and 0.05, p = 0.0003 and 0.005 respectively) but negligible or no significance with P. vivax parasite density phenotypes (Maximum: R = 0.1 p = 0.02, not significant after Bonferroni's correction and overall: R = 0.07 p = 0.25), (iii) Maximum P. falciparum density shows a positive correlation with maximum P. vivax density (R = 0.22, p = 0.0002).
The difference between the mean values of the two groups was highly significant ( P =0.0003).[ 36 ] Meanwhile, in the present study, the epidermis of HCV liver disease patients showed significantly lower thickness than the control group ( P =0.000) when measured by computer image analysis (histometry).
A second analysis considering fatty acid composition of nominally significant triacylglycerols, revealed enrichment of triacylglycerols containing C20:4, C18:2 and C16:0 in the PCOS group (p=0.0003, <0.00001 and 0.03, respectively) (also highlighted in Figure 2B ).
, both semi-conserved and variable) was highly significant ( p < 0.0003), indicating that variable SBMCs showed a strong bias for location towards the ends of chromosomes (Fig. 5 ).