These overlaps are highly significant (Fisher’s exact test, p<10 −20 ).
Excerpts
Two-by-two χ 2 tests comparing each mutant to ndt80 Δ at the same threshold confirmed that all contrasts were highly significant (χ 2 = 86.7–197.2, df = 1, p < 10 −20 ; full statistics in Table S2 ).
The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).
GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).
It exhibited highly significant associations with multiple musculoskeletal traits, most notably with appendicular lean mass ( p = 1.0 × 10 −20 ), trunk fat-free mass ( p = 1.8 × 10 −8 ), and standing height ( p = 2.0 × 10 −9 ).
We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).
As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).
Still, for the remaining animals, the differences in the number of detected SNPs were highly significant ( P < 10 −20 ).
The three large duplications in wMelPop, wMel2_a and wMel2_b were highly significant (t tests: p <10 −20 ).
The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).
Most notably, we observe a highly significant dysregulation of WNT11 →FZD1, WNT11 →FZD3 and WNT11 →FZD7 in stage II ( P -value < 10 − 20 ), as well as of WNT11 →FZD7 in stages I and II.
While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.
The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.
The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.
Each of the three possible pairwise regressions were highly significant with p<10 −20 .
Two highly significant loci mapped to chromosome 17 and chromosome 4 After the Hardy-Weinberg equilibrium test (Fisher’s exact test, P -value > 10 −20 ), 15,092,493 biallelic SNPs on all 29 autosomes remained for the GWAS.
Differential expression was also highly significant ( P < 10 −20 ) for previously described TB markers, such as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.
Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).
Nevertheless, the above fraction of 77% validated genes is highly significant with a Binomial tail p-value < 10 -20 .
Statistical testing further confirmed a highly significant increase in DSC and decrease in AVG HD for both improvements (competition and information aggregation) compared to QuickNAT (Wilcoxon signed-rank test, p < 10 −20 after Bonferroni correction for multiple testing).
[ 5 ], where they demonstrated a highly significant enrichment for genic regions within the group of loci identified as potential targets of positive selection (p < 1E-20).
The GCGC haplotype combination of the 2677G>T, 3435C>T, 1249G>A and −24C>T respectively was found to be extremely significant (p = 1.10e−20) with good drug response to CBZ mono-therapy.
A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).
The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).
The association between PRS and phenotypes of the same trait were highly significant (PRS 25-OH-D p = 1.4e − 20, PRS n3-PUFA p = 9.3e − 6, PRS MDD p = 1.4e − 4).