Excerpts

The difference between CTA and all genes was highly significant with Mann–Whitney U test p -value = 1.47E-21, and likewise for CTX versus all genes with p -value = 1.16E-23.

MR analysis in the same study provided further highly significant evidence of a causal relationship between mLOY and AF (HR: 1.15, 95% CI: 1.13–1.18, p = 1.52 × 10 −21 ).

2 B) but with a highly significant effect ( P = 1.57*10 -21 after PLS-DA cross-validation ANOVA). 3.3.

( 2017 ) overlapped with our set of 2,379, which is highly significant (hypergeometric test p = 16.8 × 10 –22 ) and suggestive of commonalities among transcriptomic stress responses, whatever the underlying trigger.

We found loci with genome-wide significant associations to EPDR1 expression in human islets (rs6965395 and rs1524054) and others that were borderline significant (rs4720265, rs3734952, rs10488617 and rs3213975 with nominal p-values = 2.5 × 10 −21 , 7.14 × 10 −21 , 4.5 × 10 −22 , 4.5 × 10 −22 , respectively).

Two highly significant DMRs (DMR1 p = 2.72E-21; DMR2 p = 1.84E-08) were discovered within the primary and alternative promotors and leading exons of the MAP2K3 gene that encodes the MAP kinase kinase, MKK3 (Fig. 4 b).

This overrepresentation of prophage DNA is highly significant (binomial test, P = 3 × 10 −21 ).

Furthermore, there was however a strong trend in CPD across age groups; cases in the uppermost quantile having a cigarette consumption of 3.2 CPD less than those in the lowest age quantile ( P = 3.01×10 −21 ).

The mean ΔPPD ( ± SE) for the bTB+ animal group was 1170.35 ± 84.48 compared to −360.46 ± 55.17 for the bTB− group and this group difference was highly significant (two-tailed Wilcoxon rank-sum test; P < 3.258 × 10 −21 ) (Supplementary Fig.

In fact, highly significant abundance of cis configurations of PFA-nsSNPs was obtained, with a global cis/trans ratio of 59.6:40.4 ( P < 3.53 × 10 −21 ) (Table 1 ).

Thus, more than 50% of TCF target genes were differentially expressed in the 2 subpopulations, reflecting highly significant enrichment for TCF1 target genes among differentially expressed genes ( P = 3.56e-21).

In monocytes, highly significant enrichment was observed for regulation of inflammatory response (GO:0050727, p = 3.95 × 10 −21 ), positive regulation of innate immune response (GO:0045089, p = 2.69 × 10 −18 ), the innate immune response-activating signaling pathway (GO:0002758, p = 2.69 × 10 −16 ), canonical NF-kappaB signal transduction (GO:0007249, p = 3.00 × 10 −9 ), and the tumor necrosis factor-mediated signaling pathway (GO:0033209, p = 0.001).

We observed a highly significant correlation between the signature count score and ME in the Test dataset (OR = 1.23 per standard deviation increase, p = 4 × 10 − 21 ) when including sex and the top 10 genetic principal components as confounders in the logistic regression.

This SNP was also highly significant in our analysis ( p = 5.4 × 10 −21 , beta = 0.27 years, effective-allele = G).

Finally, Fbp1 had a highly significant cis eQTL (rs13481847; P =6.1×10 −21 ) in the cochlea that maps ∼100 kb upstream of our peak GWAS SNP on chromosome 13 for ABR threshold after a 24-kHz tone burst.

Results demonstrated that all the three main effects were highly significant: semantic context, F (1,65) = 189.567, p = 6.12e−21, partial η 2 = 0.745; F 0 contours, F (1,65) = 277.133, p = 3.948e−25, partial η 2 = 0.81; group, F (1,65) = 22.554, p = 1.167e−5, partial η 2 = 0.258.

This is a highly significant overlap ( p = 6.14 × 10 –21 by hypergeometric probability).

Urate is relatively low down the list (27 th position), but nonetheless enough data is available to yield a highly significant (top hit p-value = 7.29 x 10 -21 ) GWAS result ( Figure 1 ).

Discussion The BCO2 mutation ( c.196C>T ) identified in the present study showed a highly significant (P = 7. 44 × 10 -21 ) association with yellow adipose tissue in 428 genotyped sheep.

GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).

There is a substantial (average coefficient -0.6) highly significant (p<10 −20 ) shift of the distribution towards negative values for contrast-dependence (bottom histogram), together with a mild (∼0.16) less significant (p<0.01) shift towards positive values for SNR-dependence (top histogram).

Most notably, we observe a highly significant dysregulation of WNT11 →FZD1, WNT11 →FZD3 and WNT11 →FZD7 in stage II ( P -value < 10 − 20 ), as well as of WNT11 →FZD7 in stages I and II.

Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).

The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.

Each of the three possible pairwise regressions were highly significant with p<10 −20 .