Barely Significant
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a clear trend

12,255 sentences · 12,255 papers · 30,749 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

For the other combinations, a clear trend was that temporal parameters (onset, offset, peak latency) and shape parameters (amplitude, ampavg, upslope and downslope) were usually not correlated as judged from the numbers across electrodes, consistent with the findings from Lang et al.
However, a clear trend in the SAR of these compounds can hardly be derived from these studies. 82 Pyrrolizidine- N -oxides have typically lower acute and long-term toxicity than the corresponding tertiary amines and both usually coexist in plants. 4 They are present in 3% of all flowering plants such as Asteraceae , Boraginaceae , and Leguminosae . 84 They play a role in chemical ecology, as pyrrolizidine- N -oxides are reduced by enzymes in the liver and microbes of the gastrointestinal tract of herbivores.
The investigational clinical pipeline, however, shows a clear trend toward the development of therapeutic antibodies that are more complex. 4–6 In addition to full-length canonical antibodies, the pipeline increasingly includes bi- or multispecific antibodies 7–10 and antibody-drug conjugates (ADCs), 11 as well as antibody fragments, fragment-Fc and appended Ig, which can be naked, conjugated to other molecules or fused to non-Ig proteins, and can have monospecific, bispecific, or multispecific properties.