“a numerical trend”

In contrast, cinnarizine showed a numerical trend toward a lower incidence of appetite reduction compared with topiramate (4.2% vs. 14.6%).

While limited by small subgroup sizes, we observed a numerical trend suggesting that EUS-HGS may offer better long-term patency when combined with EUS-GE, whereas EUS-CDS appears to be a viable alternative when ES is used.

3.75%, P = 0.33), although a numerical trend toward a higher incidence was observed in the dnDSA-positive cohort ( Figure 5C ). 4.

In the direct comparison between low-dose rivaroxaban and conventional anticoagulation, we observed a numerical trend toward lower major bleeding risk with the low-dose regimen.

In the present study, although the development of cAEs did not demonstrate a statistically significant impact on PFS, a numerical trend toward superior PFS was observed in patients who experienced cAEs compared with those who did not.

Although this difference was modest, it indicates a numerical trend toward shorter PACU stay among patients treated with acetaminophen; however, the difference was not statistically significant and should not be interpreted as evidence of clinically meaningful improvement in postoperative recovery efficiency.

Severe complications were rare and were observed predominantly in the on-clamp group, consistent with previous studies that did not demonstrate statistically significant differences in Clavien–Dindo ≥ III complications between techniques, although some reports have described a numerical trend favoring the off-clamp approach [ 22 , 24 ].

History of prior HZ showed a numerical trend towards increased incidence among patients who developed HZ in the present cohort, but significance was similarly unmet.

In our cohort, a numerical trend toward higher-grade tumors was observed in HER2-positive patients; however, this difference did not reach statistical significance.

In our cohort, the prevalence of prior cardiac and aortic surgery was notably high across all BMI categories, with a numerical trend toward more prior aortic interventions in lower-weight patients.

A numerical trend toward higher complications, particularly major bleeding (11.4% vs. 3.4%), was observed in the half-dose group, although not statistically significant.

Our pooled analysis did not detect significant differences in systolic or diastolic blood pressure between treatment groups, although there was a numerical trend toward lower blood pressure with roxadustat.

Taken together, these findings indicate a numerical trend toward poorer prognosis in patients with high SULF2 expression.

Among 205 patients surviving at least 7 days, Lille scores did not differ significantly between the bilirubin-driven and PT-driven groups (mean 0.256 vs 0.292; P = .17 by t -test, P = .10 by Wilcoxon test), though the bilirubin-driven group showed a numerical trend toward higher scores.

In contrast, treatment category was not significantly associated with survival status ( p = 0.074), although a numerical trend toward improved outcomes was observed in patients receiving standard therapy with or without immunotherapy.

However, in LIBERTY-CSU CUPID study B, which included patients with CSU who were intolerant or incomplete responders to omalizumab, although a numerical trend was observed, the primary endpoint of change from baseline in ISS7 at week 24 was not met [ 19 ].

In contrast, length of stay and readmission were not statistically significant in the primary pooled analyses, although length of stay showed a numerical trend favoring alvimopan.

Total hospital costs did not differ significantly between groups, although a numerical trend toward higher costs was observed in the hypoglycemia group.

Although not statistically significant, the ESRD subgroup showed a numerical trend toward higher LDL-C in TT carriers, which is directionally consistent with the overall analysis.

A numerical trend favoring the OZ NPI over the total NPI was observed, although this difference did not attain statistical significance.

6 Elafibranor Elafibranor, a dual PPARα and PPARδ agonist approved by the FDA in June 2024 and by the EMA in September 2024 for the treatment of PBC, 26 , 27 showed a numerical trend towards pruritus improvement but did not achieve statistical significance for its primary pruritus end point.

Despite the lack of statistical significance, riociguat replacement therapy showed a numerical trend toward greater efficacy in preventing clinical worsening than selexipag add-on therapy.

Similarly, while advanced age did not reach multivariable significance ( p = 0.094), it demonstrated a numerical trend in our model.

Although these differences in ORR did not reach statistical significance (Chi-square p = 0.08, likely due to limited power), a numerical trend is evident.

The exploratory subgroup analysis suggested a numerical trend favoring paclitaxel-ramucirumab among patients who experienced neuropathy during first-line treatment.