Barely Significant
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“a numerical trend”

1,013 sentences · 1,013 papers · 1,817 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

tion or no clearly documented rationale; (iii) among patients with non-bleeding-related de-escalation, the rationale for switching to clopidogrel was often reasons that could have been addressed with the use of prasugrel to avoid the switch and prevent exposure to ischemic risks; and (iv) there was a numerical trend for increased myocardial infarction among patients with non-bleeding-related de-escalation.
The study was not powered to demonstrate an EFS benefit, but an exploratory analysis at 5-year follow up showed a numerical trend in favor of the docetaxel/trastuzumab/pertuzumab arm compared with docetaxel/trastuzumab (84% versus 81%; HR 0.69; 95% CI 0.34–1.40). 40 TRYPHAENA was a three-arm study enrolling 225 patients with HER2+ tumors 2 cm or larger. 39 It primarily aimed to evaluate the cardiac safety of three pertuzumab and trastuzumab-containing regimens.
21 , 40 In our study, EFS analysis stratified by pathological response showed a numerical trend toward better outcomes in MPR patients (median EFS 18·5 months) versus non-MPR (16·1 months), though the difference was not statistically significant, likely due to the modest sample size and short follow-up.