In the IMspire150 study, triple therapy showed a significantly better PFS in patients with elevated LDH as well as a numerical trend towards better outcomes in patients with a high tumor mutational burden [ 30 ].
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“a numerical trend”
Sighted at
p=0.09
In the literature
Safety analysis did not report any significant rise in serious adverse event risk, hypoglycemia, or decompressive craniectomy risk, although a numerical trend for more hypoglycemia was observed in the glibenclamide group.
If anything, there was a numerical trend in the opposite direction, which, however, failed to reach significance.
In contrast, although reductions in pork toughness and firmness were observed in these groups, these differences did not reach statistical significance, indicating only a numerical trend toward improved texture.
There was a numerical trend toward earlier improvement in the ADA – MTX and ADA + MTX new users compared with the MTX new users, resulting in lower mean disease activity in the first 12 months of registry follow‐up in ADA – MTX and ADA + MTX new users.
There was a numerical trend for higher proportions of patients with eosinophil counts of ≥300 cells/μL with a history of 1 (41.0%) or ≥2 (39.4%) exacerbations compared with no exacerbations (25.0%).
The FFT transformation converts the maximum frequency amplitude from its peak value to the maximum magnitude, producing a numerical trend similar to the maximum magnitude.
tion or no clearly documented rationale; (iii) among patients with non-bleeding-related de-escalation, the rationale for switching to clopidogrel was often reasons that could have been addressed with the use of prasugrel to avoid the switch and prevent exposure to ischemic risks; and (iv) there was a numerical trend for increased myocardial infarction among patients with non-bleeding-related de-escalation.
The study was not powered to demonstrate an EFS benefit, but an exploratory analysis at 5-year follow up showed a numerical trend in favor of the docetaxel/trastuzumab/pertuzumab arm compared with docetaxel/trastuzumab (84% versus 81%; HR 0.69; 95% CI 0.34–1.40). 40 TRYPHAENA was a three-arm study enrolling 225 patients with HER2+ tumors 2 cm or larger. 39 It primarily aimed to evaluate the cardiac safety of three pertuzumab and trastuzumab-containing regimens.
There was a numerical trend towards Other, Pacific Peoples and Asian patients having proportionally more proliferative (class III/IV) LN [ n = 1/1 (100%), n = 9/10 (90%), n = 16/20 (80%), respectively] compared with NZ Europeans [ n = 2/6 (33%)] ( P = 0.11).
2.00 (1.00–3.00); P=0.059], although a numerical trend toward improved mood and anxiety symptoms was noted in the observation group ( Table 5 ).
Validation experiments showed that there was a numerical trend toward significance when OA was compared to controls.
However, patients in the late era showed a numerical trend toward improved survival outcomes compared to those in the early era.
Although no statistically significant difference was observed among the three groups, the weight-based TXA group exhibited a numerical trend toward a longer tourniquet application time compared with the other two groups.
4 ) and a numerical trend in GFAP immunostaining (Fig. 4 and representative images in Supplementary File 8 ).
Although we did find a numerical trend toward the risk of common infections in GG patients, this trend was surprisingly weak both in terms of infections of non-gastrointestinal organs and in terms of CD-specific infections ( Table 3 ).
A numerical trend favoring the OZ NPI over the total NPI was observed, although this difference did not attain statistical significance.
A comparison between re-paired and novel context condition was not significant, t (41) = 1.91, SE = .25, p = .06, d = 0.31, but a numerical trend (which was significant in Experiment 2) suggested longer termination latencies for the re-paired context condition.
There was a numerical trend for the enrichment of responses in models with low tATM H scores by IHC for AZD6738 monotherapy (38% low vs. 0% high) but no differential for a combination where high tATM models showed >50% TGI responses (63% low vs. 67% high) but with the caveat of a low number of models.
This transformation makes it easier to detect any subtle group differences, though in this case the group means remain statistically non-significant ( p = 0.102), though a numerical trend persists.
3 A) and a numerical trend toward increased CYP2C9 activity with increasing PCB74 plasma concentrations (Fig. 3 B).
Additionally, there was a numerical trend toward reduced protein and energy retention at the highest SCP inclusion and this effect was significant in the second experiment.
The ANOVA gave a p value of 0.054 indicating that, although there was a numerical trend towards lower tensile strength for 10 and 20% substitution cements, there was no statistically significant difference between these values and those of the other GICs.
There was a numerical trend towards increased F4/80+CD11b+ macrophages/monocytes in the spleen and blood on days 2 and 7, respectively, though these data were not statistically significant.
21 , 40 In our study, EFS analysis stratified by pathological response showed a numerical trend toward better outcomes in MPR patients (median EFS 18·5 months) versus non-MPR (16·1 months), though the difference was not statistically significant, likely due to the modest sample size and short follow-up.