“a numerical trend”

There was also a numerical trend evident for the three groups independently (Table 2 ) with 5.13% versus 2.38% for severe CRS (relative risk 1.679; 95% CI 0.947–2.583), 5.77% versus 4.28% for severe CRS and NT (relative risk 1.247; 95% CI 0.6874–2.004), and 9.62% versus 5.94% for severe NT (relative risk 1.428; 95% CI 0.9038–2.085) although not reaching statistical significance.

8 In another phase 3 study ( NCT00337103 ), eribulin-treated patients did not have a significant improvement in OS as compared to patients treated with capecitabine in the first, second, or third line of chemotherapy in the metastatic setting, although a numerical trend favoring eribulin was demonstrated. 9 Interestingly, in a subsequent pooled analysis of both of these trials, eribulin was seen to have a significant improvement in OS, as compared to the control arm.

In female patients assigned to mGPS category 1 or 2, a numerical trend towards longer OS was also observed in Arm A compared to Arm B, however, with statistical testing not revealing a significant survival difference between treatment arms (24.6 versus 16.7 months; P = 0.15) ( Supplementary Table S1 , available at https://doi.org/10.1016/j.esmoop.2024.103374 , Figure 4 A and B).

This long-term, prospective, randomised, head-to-head trial demonstrated a numerical trend for increased risk of MACE and VTE (only the 10 mg dose), among other serious adverse events, for the JAK inhibitor tofacitinib compared with TNF inhibitor therapy in a population enriched for CV risk (patients who were aged ≥50 years with at least one CV risk factor). 16 The increased relative ris

15 Final OS results show a numerical trend favoring ipatasertib–paclitaxel (median OS 23.1 vs 18.4 months in ipatasertib vs placebo arm, stratified HR 0.62 [95% CI, 0.37-1.05]). 33 However, the Phase III IPATunity130 cohort A failed to show PFS benefit from the addition of ipatasertib to paclitaxel in patients with mTNBC harboring PIK3CA/AK

Furthermore, a numerical trend toward higher chronic kidney disease in the urgent group was evident.

A numerical trend favoring birtamimab in the primary composite end point for the overall population was observed and was hypothesized to be driven by a treatment effect in the most advanced patients (Mayo stage IV).

While a numerical trend in favoring prolonged ET for patients with a higher CTS5 was found, a significantly predictive value for the score could not be confirmed.

While they did not observe a statistically significant reduction in OS by Kaplan-Meier analysis, there was a numerical trend towards reduced survival in patients whose tumours demonstrated ZNF331 methylation.

While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).

Nonetheless, those patients who had ≥12 months of PFS during prior palbociclib‐based therapy only had a numerical trend towards PFS improvement compared with those patients who had less than 12 months of PFS during prior palbociclib‐based therapy (median PFS: 7.0 vs. 5.0 months, log‐rank p = 0.931).

In women, ever smokers and smoking amount showed a numerical trend towards lower risk of death and hospitalisation, but were only significantly associated with respiratory hospitalisation (Additional file 1: Table S2 and Table S3 ).

Although statistically significant prognostic comparisons were limited by the small sample size in our internal cohort and MYC status was only evaluable at the time of recurrence, there did appear to be a numerical trend towards worse median survival with MYC amplification, as well as higher rates of recurrence, despite the majority of patients ultimately receiving immunotherapy in addition to chemoradiotherapy, conforming with previous observations 36 .

There is a numerical trend indicating that flumazenil-associated encounters required more interventions to improve ECT effects compared with nonflumazenil encounters, including lead placement change and caffeine provision.

There was a numerical trend toward a smaller change in monthly migraine headache days after treatment discontinuation as the treatment duration increased.

Besides the bias towards a lower real-time CO, real-time measurements showed a numerical trend towards a better agreement with the reference standard compared to the other CMR techniques.

While there was no significant difference regarding ischemic events, a numerical trend towards a higher number of early ischemic events was observed between the two groups [ 23 ].

Although the differences in other ocular symptoms upon instillation were not statistically significant, there was a numerical trend in favor of PFB 0.01% gel for stinging, tearing, and foreign body sensation.

The main effect of text justification was not significant though there was a numerical trend suggesting that return-sweep landing position was closer to the left margin of a new line in the left-justified condition than the fully-justified condition.

There was no significant difference in rate of recurrent ischemic events at 90 days for patients who were DWI positive versus negative, though there was a numerical trend toward higher recurrence rate with DWI positivity.

We evaluated age- and sex-related differences in chronic cough, finding a significantly higher prevalence of chronic cough among females and a numerical trend of increasing prevalence of cough in the prior 12 months with older age.

72 The rates of ischemic events were similar in the two groups and a numerical trend, albeit not significant, toward less bleeding in the platelet function-guided group was evident.

ISR incidence decreased over time regardless of BMI group or dosing regimen, with a numerical trend toward fewer ISRs in the higher BMI group overall ( Figure 1 ).

However, at sensitivity analysis excluding those two studies from our analysis, results showed to be consistent with the absence of any significant difference between the two groups, even though a numerical trend emerged in favor of immediate (single-stage) complete revascularization for the composite endpoint of all cause death, repeat revascularization and MI ( Supplementary Fig. 9 ).

A numerical trend was seen for higher albumin levels at vedolizumab LOR among patients undergoing subsequent medical (median 4.1, IQR 3.9–4.4 g/dl) compared to subsequent surgical therapy (median 3.9, IQR 3.17–4.1 g/dl, p = 0.24).