“a significant trend”

There was a significant trend ( p < 0.001) for p16/Ki67 positivity and increasing histological severity of the lesion: this was observed in 11.5% of histology-negative cases, in 18.7% of CIN1 cases, and in 94.6% of CIN2+ cases detected on histology.

We observed an increase in the choice of laparoscopic approach during the study period (2016: 12%, 2017: 13%, 2018: 15%, 2019: 23%) and found a significant trend ( p < 0.001) in the Cochran-Armitage test (Fig. 2 ).

066), and a post hoc linear contrast showed a significant trend ( F (1,94) = −6.02, β = −3.33, p < .001), indicating that there was a linear relationship among the corrected recognition scores to novel picture categories.

On a categorical scale, four-year hazard ratios (95%CI) for MACE were significantly higher with CS_top than with CS_low (4.82(3.39-6.85), p < 0.001), which was also the case for all-cause death, cardiac death, myocardial infarction, and ischemia-driven revascularization; for all these endpoints, there was a significant trend ( p < 0.001) for higher event rates with increasing CS tertiles as shown in Figure 2(A–E) .

A significant trend for higher Klotho levels with higher intake of a specific nutrient was found for carbohydrates ( p < .001), total sugars ( p < .001), dietary fibers ( p < .001), vitamin D ( p = .05), total folates ( p = .015), and copper ( p = .018) (Table S2 ).

Concentration of ctDNA was significantly different between stages of disease [ H (3) = 15.307, p = 0.002], with a significant trend of increasing ctDNA concentration associated with more advanced disease at diagnosis defined by NCCN clinical stage ( J = 1103.5, z = 3.737, p < 0.001, r = 0.46) (Fig. 2 ).

Using a generalized additive mixed model (GAMM 51 ), which accounts for the temporal structure within the data by specifying a correlation structure (corAR1), we test for change in the estimated size of the projected potential climatic niche space through time, from 145 ka to 30 ka ago and find a significant trend ( r 2 = 0.373, edf = 2, p < 0.001), in which as time progresses, there is a general pattern of contraction from the Eemian onwards (Fig. 5 ).

We observed a significant trend toward using a higher sun protection factor (SPF) in melanoma patients compared with at-risk patients (SPF 50+: 48% [n=60] vs. 26% [n=37]; p=0.0016).

We observed a significant trend in which the number of patients with a low-ALRI value increased as the stage progressed (RFS: p = 0.002) (Table 4 ).

This interaction revealed a significant trend for increased performance with reading age after regular primes in children with TD, trend = 1.26, SE = 0.40, p = 0.002, z -ratio = 3.13, r = 0.48, 95% CI around effect size [0.20, 0.66], but not after irregular primes in children with TD ( p = 0.28) and not in children with DLD after regular ( p = 0.35) or irregular ( p = 0.10) primes.

A significant trend change was detected in the Diabetes group ( P = 0.002), and the trajectory of 5-Year MACE Survival changed from a negative slope to a positive slope.

Notably, there was a significant trend of decreasing prevalence of MetS with increasing quartiles of CDAI (p = 0.002).

From that, we observed a significant trend (Cochran–Armitage test P value = 2.6 × 10 −3 ) whereby newly acquired genes appeared more frequent than ancestral genes in these regions ( Fig. 6A ).

A significant trend ( p = 0.003) was observed that highlighted the relationship between the ropivacaine dose and the incidence of breakthrough pain.

We observed a significant trend in better ORR to ICI according to the DDR-GA status: 1/11 (9%) patients in UPa, 5/17 (29.4%) patients in PPa, and 9/20 (45%) patients in Pa ( P = .003, Cochran-Armitage trend test), and an increased 6-month PFS probability of 11%, 44%, and 50% in the UPa, PPa, and Pa groups, respectively ( P = .37, log-rank test).

Notably, a significant trend was observed across the different CAR categories ( P = 0.003; Table 2 ).

In the fully adjusted model (Model 3), compared to the first quartile, individuals in the highest quartile of OBS exhibited a negative association with 10-years ASCVD (OR: 0.59, 95% CI: 0.42–0.83, p = .002), with a significant trend ( p = .003).

Although the antihypertensive treatment with the use of 2800 IU daily was not effective, a significant trend of an inverse association between the achieved 25(OH)D concentration and systolic pressure was noted ( p = 0.003).

Change in the hunt and hess grade Throughout the decades of the study period, ANOVA analysis of the HH good grade showed a significant trend in the severity of aSAH, with the percentage of patients presenting with HH good grade decreasing by an average of 5.49% per decade ( p = 0.004).

Factors Associated with DAO Levels When considering the median DAO, a significant trend of increasing DAO was seen with increasing BMI ( p = 0.004) and increasing age ( p <0.001), where the group >61 years were found to have a higher DAO than other age groups ( Figure 2 ).

In one study, this delay in culture conversion was dose-dependent [ 42 ], with a significant trend of increasing AOR ( p = 0.004) with greater smoking, rising to an AOR of 11.6 and 95% CI 1.8–73.4 in those smoking more than 20 cigarettes a day.

In particular, when compared to physiological range, the autonomous sitting acquisition was delayed in 63.2% of the patients, with a significant trend in male patients ( p = 0.005).

A similar positive association was identified between increasing quartile of time spent in total PA and thicker mGCIPL: participants in the second highest and highest quartile (i.e., quartiles 3 and 4) showed thicker mGCIPL by +0.18 μm ( P = 0.016) and +0.16 μm ( P = 0.029), respectively, compared with those in the lowest quartile, with a significant trend ( P = 0.005 for trend).

Organ meat intake and NASH In univariable and multivariable logistic regression models ( Table 3 ), there was a significant trend (P=0.005) for the association between higher animal organ meat consumption and lower risk of having definite NASH.

The method stated that although there was significant variability between tests, a significant trend was observed for Aniseikonia Inspector ( R = 0.63, R 2 = 0.40, p = 0.005) and New Aniseikonia Tests ( R = 0.54, R 2 = 0.29, p = 0.017), with subjective aniseikonia increasing as disparity increased.