“a significant trend”

A significant trend was identified for LprI_01601/TehA ( χ 2 = 4.52, P = 0.033; Additional file 2 : Figure S8B) and a borderline non-significant trend identified for 01601/TehA operon ( χ 2 = 2.69, P = 0.10; Additional file 2 : Figure S8C).

Only the values of LDH and CXCR4 expression showed a significant trend (P = 0.033 and P = 0.003, respectively).

Figure S6 The relationship between temperature, wing nutritional plasticity and FOXO expression in wild-type Drosophila (A) In wild-type larvae, an increase in rearing temperature leads to a decrease in FOXO expression in the wing imaginal discs (linear regression, p <0.001) (B) As temperature increases there is a significant trend towards decreased nutritional plasticity of the wing in wild-type flies (permutation test p = 0.033).

However, the highest tertile (T3) of HbA1c was significantly associated with increased odds of HF in Model 1 ( P = 0.034) and Model 3 ( P = 0.028), with a significant trend observed in these two models ( P < 0.033).

Subgroup analysis (tracer type, molecular subtype) was corrected using Bonferroni, and the corrected P -value threshold was 0.05/2 = 0.025: The original P = 0.037 in the tracer group → adjusted P = 0.074 (with a significant trend), and the original P = 0.033 in the molecular subtype → adjusted P = 0.066 (the differential trend still exists).

There was a significant trend towards more severe pruritus among poor responders compared with good responders ( p = 0.033), with a higher proportion of poor responders reporting moderate to severe symptoms.

Furthermore, the Jonckheere–Terpstra test showed a significant trend ( p = 0.0337) of an age-dependent decrease in sIgA levels.

Overall survival differed significantly by tumor type (p = 0.0395), with a significant trend across groups (p = 0.0340).

Separate trend analyses showed a significant trend in the non-obese group (χ 2 1 =4.520, P=.034) and no significance in the obese (χ 2 1 =0.679, P=.410).

When ANC maximum was measured, there was a significant trend ( P = 0.034) for the maximum ANC level achieved in stage II during cycle 1.

The multivariant adjusted model in NHANES found a significant trend ( P = 0.034) in increased risk for developing breast cancer across the four quartiles of urinary cadmium ( 52 ).

As demonstrated by linear regression model in Table 4 we observed a significant trend that survivors with CCI ≥ 1 ( β = 5.2, p = 0.034), tumor sits at nasopharynx ( β =-9.1, p = 0.034), or treated by 2DRT ( β =-12.2, p < 0.01) had a higher probability to report a high level of xerostomia.

The OR for the highest vs the lowest quintile of GI was 2.1 (95% CI: 1.2–3.6), with a significant trend in risk ( P =0.034).

When investigating the interaction between allocation and time, only actigraphy-measured sleep efficiency showed a significant trend over time ( p =.034).

At day 3 a significant trend of increased expression was observed for COL2A1 ( p = 0.034) and COL10A1 ( p = 0.012) with wildtype GDF5, and for COL2A1 ( p = 0.0068), MMP1 ( p = 0.037) and COL10A1 ( p = 0.027) with GDF5 variant.

Also, there was a significant trend towards less advanced nodal disease in the neoadjuvant group than in the adjuvant group ( P = 0.034) ( Table 3 ). 3.5.

Using water Mn concentrations as a continuous variable, the adjusted OR was 0.75 (95% CI 0.58–0.98, model I) per 1 mg/L (1,000 μg/L) increase in Mn concentration, with a significant trend ( P =0.034).

A significant trend towards decreased survival in patients with alcohol history compared to the patients without alcohol history, 42.3% vs. 76.9% (p=0.034), and a decreased survival rates in p16 negative patients compared to p16 positive patients, 43% vs. 69.7% (p=0.034) was noticed.

A significant trend towards better local control in hypoFx patients could be observed (overall LC 58.2% for nFx vs 90.5% for hypoFx, HR = 0.15, 95%CI: 0.02-0.86, p = 0.034) and high-dose PTV volume > 60 cm3 was a significant risk factor for locoregional progression (Figure 1). 11 patients (28.9%) developed ≥ G3 serious late complications, mostly soft tissue necrosis and infections which eventually improved in 6 of them.

For TTP as well as OS, there was a significant trend for increased survival in relation to increased expression of MHC II by the tumour ( P =0.034 and 0.043, respectively; log rank test for trend).

PFS analysis by quartiles of PLCγ1 expression [Q1 (0%–25%), Q2 (25%–50%), Q3 (50%–75%), and Q4 (75%–100%)] showed a significant trend that higher-expression patients progress faster under cetuximab therapy (log-rank test for trend, * P = 0.0340), with a clear distinction between Q1–2 versus Q3–4 patients (Supplementary Fig.

A significant trend indicating increased Nef-mediated SERINC5 downregulation function correlated with higher viral load was observed in subtype B viruses ( r = 0.6685 and P = 0.0346, Fig. 2 e).

There was a significant trend of TBUT improvement over the 12 weeks ( P =0.035) with no significant difference between treatment groups ( P =0.88).

When relative declines in serum CA125 levels were cross-tabulated with surgical outcome, a significant trend towards greater declines in those with a better surgical outcome was found (p=0.035) ( Fig. 2 ). 2.

When analyzed as a categorical variable, the multivariable- AOR from the lowest to highest quintiles of percentage energy from carbohydrate were 1 (reference), 1.062 (95% CI: 0.892–1.264), 1.263 (95% CI: 1.031–1.546), and 1.411 (95% CI: 1.083–1.839), with a significant trend ( P = 0.035).