a trend toward significancep = 0.068
In the multivariable model, there was a trend toward significance for disease progression (HR 1.41, 95% CI: 0.97–2.04; p = 0.068), and there was an increase in the risk of death (HR 2.20, 95% CI: 1.29–3.74; p = 0.004) with higher levels of LDH.