Barely Significant
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almost reached significance

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almost reached significancep-value = 0.061.2× alpha
Association between high CD73 expression and worse disease-free survival (DFS) almost reached significance compared with those with low CD73 expression (p-value = 0.06, HR = 1.66, 95% CI = 0.982–2.8) in the control arm but not in the zoledronic acid arm (Fig. 2 C, D; Table 3 ).
almost reached significancep = 0.0611.2× alpha
In the general linear model of repeated measures for the dependent variable VAS, the difference in the use of headache medication between pre- and post-treatment as a covariable and the group and time as factors, there were not any significant main interactions; however, the interaction between group and time almost reached significance ( p = 0.061).
almost reached significancep = 0.0811.6× alpha
Of the seven included global scores (reading accuracy, reading speed, writing accuracy, phonemic awareness, memory and callosal transfer), a significant difference emerged for Global writing accuracy ( p = 0.029, partial eta square = 0.033), while Global reading accuracy and Global phonemic awareness almost reached significance ( p = 0.081, partial eta square = 0.023 and p = 0.071, partial eta square = 0.021, respectively).
almost reached significancep = 0.0841.7× alpha
Multivariable analysis revealed that only tumor stage was significantly associated with pathological response to chemotherapy ( p = 0.032), although HER2 status and clinical response as a continuous variable almost reached significance ( p = 0.084 and p = 0.063, respectively).
However, the difference in NPO at 3-month follow-up between the 2 groups almost reached significance (Cuidándome: mean 5.45, SD 3.15 vs comparison: mean 7.66, SD 4.82; P =.09), and we estimated small (T1: d =0.10) and medium (T2: d =0.54 and T3: d =0.38) effect sizes ( Table 4 ).