“an increasing trend”

Reported pain was frequent across the years, affecting 70% of patients with an increasing trend ( p < 0.001).

For the scale of Enrollment , most interventional trials were small-scale (enrolling 1–100 participants) and showed an increasing trend over time ( Z = 3.96, p < 0.001).

This occurred amid an increasing trend of central obesity in boys (P<0.001).

−0.06% ± 0.04%, P < 0.001) with an increasing trend in higher grades ( P < 0.001).

There was an increasing trend of FMD < 8% from control, LDH1, LDH2 to LDH3 group ( χ 2 = 36.751, p < 0.001).

The proportion of AMI admissions involving CUD saw an increasing trend ( P = 0.001) from 2198 (in 2010) to 2900 (in 2014), representing a 32% increase over five years.

The cytotoxicity also had an obvious correlation with culture time ( r (5) = 0.968, P < 0.001), and exhibited an increasing trend with extension of culture time ( F (5, 13) = 117.584, P < 0.001).

Mobile phone use showed an increasing trend with increasing mother’s and father’s education (both p < 0.001).

There was an increasing trend in energy intake among tertiles of TAC, with subjects in the third tertile having significantly higher values of total energy intake ( p < 0.001 for all comparisons); therefore, appropriate adjustments were performed to interpret the data.

The two-decade trajectory reveals an increasing trend in global mining-driven deforestation from 2001 to 2012 ( + 90.26 km 2 /year, p < 0.001), followed by a decline since 2013 (−50.73 km 2 /year, p < 0.001) (Fig. 2d ).

Among all participants, hr-HPV, lr-HPV infection, as well as single and multiple infections, demonstrated significant differences and an increasing trend during the same period ( P < 0.001; Table 1 ; Fig. 2 ).

1 A–C, there are differences in PSMC4 expression levels across LGG of varying grades, with an increasing trend in PSMC4 expression as the malignancy of the tumor increases ( P < 0.001).

The results revealed that the expression of hsa-miR-372-3p was significantly increased in the NSCLC and LUAD tissues, but only exhibited an increasing trend in the LUSC tissues (NSCLC P<0.001, LUAD P=0.017, and LUSC P=0.243) ( Fig. 16A ).

Regarding SD clusters, we found an increasing trend in ORx and OSRx average within 60 min just before SD clusters, as seen in the positive slopes derived from the fitted linear mixed-effects model (0.0013 [ p = 0.001] for ORx and 0.0009 [ p = 0.0001] for OSRx, respectively; Table 2 ) We also found a decreasing trend in ORx within 60 min just after SD clusters (− 0.0008, p = 0.0288) but no significant trend in OSRx post-SD clusters.

Time from emergency presentation to emergency ureteric stent remained unchanged, however, proportions of procedures performed out-of-hours showed an increasing trend ( P < 0.001).

Changes in DDDs Figures 2a,b show that before policy implementation, evolocumab exhibited an upward trend in DDDs (β 1 = 2931.563, P < 0.001), while alirocumab also demonstrated an increasing trend (β 1 = 833.907, P < 0.001), albeit less pronounced than that of evolocumab.

An increasing trend in the h* values during storage time and until the ninth day was assessed in the present study, the h* parameter raised ( p ≤ 0.001) indicating gradual oxidation of myoglobin and accumulation of metmyoglobin with time [ 71 ].

Results A total of 4388 juvenile European hedgehogs were admitted to 27 wildlife rehabilitation centres in the Czech Republic in the period from 2011 to 2020, with an increasing trend in the number of juveniles admitted per year during the entire period (rSp = 0.9879, p < 0.001).

Kruskal–Wallis test shows an increasing trend of attrition score with increasing age (p-value <0.001).

The association between PLR, NLR, MLR, SII and all-cause mortality and cardiovascular mortality The Kaplan–Meier curve revealed an increasing trend in long-term all-cause mortality and cardiovascular mortality rates with higher levels of PLR, NLR, MLR, and SII ( P < 0.001, Fig 3 – 4 ).

On trend analysis, only serum IL-2, IL-6, and log serum APN levels showed an increasing trend for serum cytokines (all P < 0.001).

The MP‐NN score showed an increasing trend from HC to LUAD, with significantly higher scores in patients with LUAD than those in HC and LBD ( p < 0.001, Figure 2B ).

There was an increasing trend in both age-standardized prevalence (beta = 3.176, p < 0.001) and age-standardized DALY (beta = 1.829, p < 0.001) rates of OUDs in MENA from 1990 to 2019.

T1 accuracy showed an increasing trend with lag [ F (4, 120) = 12.3, P < 0.001].

Co-colonization with two or more serotypes of lytA -positive samples over increasing post booster PCV13 time intervals showed an increasing trend (χ 2 for trend P < 0.001); this was also the case among lytA - and SP2020-positve samples (χ 2 for trend P = 0.002) (Supplementary Table S2 ).