Barely Significant
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“an increasing trend”

63,972 sentences · 63,972 papers · 107,686 search hits before verification · confirmed specimen

Sighted at

p<0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

While 3T3-L1 cells co-cultured with hucMSCs exhibited an increasing trend in mRNA and protein levels of PPARG, CEBPA, CCAAT/enhancer-binding protein beta (CEBPB), FABP4, Fatty acid synthase (FASN), and Acetyl-CoA carboxylase 1 (ACC1) during the initial 72 h of differentiation, these levels were significantly lower than those in 3T3-L1 cells undergoing differentiation at the same time points (Fig. 3 d–e).
Globally, the prevalence of GERD in 2019 was 9574.45 per 100 000 people, with an increasing trend of 0.105% per year since 1990. 1 In Southeast Asia, the prevalence of GERD in 2005-2010 was 6.3%-18.3%. 2 GERD is the most common outpatient diagnosis, with the number of visits reaching 9 million visits.
9 , 10 With the influx of newer biologic and small molecule therapies, there has been an increasing trend towards combining medications for the management of refractory cases. 11 , 12 This modality appears to be effective for inducing remission of active disease and in patients with significant extra-intestinal manifestations or concomitant rheumatologic disease. 12 , 13 While there is limited data on the use of multiple biologics or JAKi in combination to treat patients with IBD, there is much less information available to guide the successful de-escalation of combination therapy once adequate response is achieved.