Results During the pandemic period, the total Beck Depression Scale values increased significantly in the patients with epilepsy compared to the pre-pandemic period ( P = 0.048), and depressive symptoms showed an increasing trend ( P = 0.032).
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For types 1 and 3, a declining trend was observed with increasing age while type 2 demonstrated an increasing trend with age which achieved level of significance ( p = 0.032) between younger and older cohorts.
The annual overall crude incidence was 5·83 per 100 000 inhabitants, with an increasing trend ( P = 0·033).
The average incidence of work-related mental and behavioral disorders was 35.48 per 100,000 RGPS links during the period 2003-2019, with an increasing trend (APC = 9.67%; p = 0.033) for Brazil.
post: 0.963 ± 1.736, p = 0.125, Cohen's d = −0.442, adjusted 95% CI of difference: −2.225 to 0.230) but an increasing trend could be found in IPL (pre: 0.814 ± 1.336 vs. post: 1.789 ± 1.167, p = 0.033, Cohen's d = −0.589, adjusted 95% CI of difference: −1.875 to −0.074).
There was an increasing trend for stage I diagnoses in the region of Campinas ( p = 0.033).
When analyzing the approved values, there was an increasing trend in the previous period ( p = 0.033), soon after there was no significant change ( p = 0.254) and no significant change in the pattern in the later period ( p = 0.155), although apparently there is a breakpoint on the day of the disaster, which is not significant (Fig. 4 ).
Whereas in comparison to baseline (T0) reduced relative abundance at the end of the study (T3) was noted in the case of Actinomycetota (from 2.1 to 0.7%; p = 0.016), Eggerthellaceae (from 1.9 to 0.5%; p = 0.008), and Enterorhabdus (from 1.2 to 0.4%; p = 0.009), an increasing trend from pretreatment (T1) was presented by Ruminoccus (from 1.3 to 3.2%; p = 0.033) ( Figure S2 ).
There was an increasing trend in the proportion of male patients over years (R 2 = 0.448, p = 0.034), while the average age showed a modest decline, which however, was not statistically significant (R 2 = 0.158, p = 0.256; Fig. 2 ).
In addition, for the proportion of apoptotic cells in the total PBMCs, the HIGH group showed a decreasing trend, while the LOW group showed an increasing trend, resulting in a significant difference in the change ( p = 0.034; Figure 2 ). 3.4.
The repeated measure ANOVA showed that there was an increasing trend in MBP of NS group ( P = 0.034), while it was decreasing in all three intervention groups ( P < 0.05; Figure 2 ).
The evidence for an increasing trend in point estimate was weaker after the association is fully adjusted for other diabetes risk factors (OR linear effect 1.10, 95% CI 1.01 to 1.19, p=0.034).
Therefore, we performed further analysis and found that after postoperative day 107, the risk of cumulative ischemic events showed an increasing trend according to the number of CYP2C19 LOF alleles (hazard ratio, 6.176; 95% CI of ratio, 1.145 to 33.32; P = 0.0342; Fig. 1D ).
In addition, Lin et al ., observed that, among maintenance hemodialysis patients, the GSTM 1 null genotype was associated with a significantly lower antioxidant capacity than the GSTM+ genotype.[ 20 ] The null/low polymorphisms of the GSTM 1 and GSTT 1 genes have been associated with the risk of developing ESRD in North Indian patients.[ 17 ] In addition, Singh et al ., reported that patients with transplant therapy demonstrated an increasing trend toward carrying the GSTM 1 null genotype (51.3%) versus healthy controls (40.4%) with a risk of about 1.5-fold ( P = 0.035), and patients with a variant genotype of GSTM 1 were at the higher risk of transplant rejection.[ 21 ] The frequencies of important functional mutations and alleles result in broad ethnic variation.
Results The incidence of CP was 68 of 9701 (0.7%), with an increasing trend over the two 5.5-year periods studied (24 of 4661 (0.5%) vs 44 of 5040 (0.9%); p=0.035).
Results: There was an increasing trend of surgical fixation of humeral shaft fractures during the 15 years' study period (β = 1.266, 95% CI 0.17 to 2.36, p = 0.035).
By contrast, an increasing trend in stunting was observed in municipalities with a very high MHDI value (10·6 %, P = 0·035).
Among the new cases of leprosy detected, the proportion of MB cases was relatively high throughout the 15-year period investigated, with an increasing trend from 62% in 2000 to 87% in 2014 (P = 0.035).
In annual ICU hospitalized patients, an increasing trend was observed in the age group 7-12 years ( tau =0.643, P =0.0354) ( Table 4 ).
Whilst no temporal or seasonal trends in monthly isolation rates were detected, either for individual infection types or in aggregate ( p > 0.1 using Bartel’s rank test), the 3GCR frequency showed an increasing trend ( p = 0.036 using Bartel’s rank test for trend, see Fig. 1a ), rising from mean 15% (range 10–21% per month) in the first nine months of the study to mean 34% (27–46% per month) in the final three months ( p = 0.0002, using test of difference in proportions of 3GCR between the two periods).
Following an increasing trend of cirrhosis-related mortality before the pandemic, with a semiannual percentage change (SAPC) of 0.54% [95% confidence interval (CI): (0.0–1.0%), p =0.036], a precipitous increase with seasonal variation occurred during the pandemic (SAPC 5.35, 95% CI: 1.9–8.9, p =0.005).
Secondary analyses An increasing trend of postpartum suicide attempt was indicated among adolescent fathers (aged 11–19 years) (IRR 1.06 (1.00–1.11), P = 0.037), but the association is no longer significant after adjusting for multiple comparison (adjusted P = 0.096).
The unit cost of high-risk population intervention showed a declining trend over the years (r=−0.791, p=0.034) (see online supplementary appendix C), while the unit cost of public awareness showed an increasing trend over the years (r=0.785, p=0.037) (see online supplementary appendix D).
There was an increasing trend in the use of early CAG over the years ( p = 0.037 for trend). 3.2.
aeruginosa showed an increasing trend over time ( Rs=0.738, P=0.037 ).