borderline significanceP = 0.06
RT-qPCR confirmed induction of NOTCH/TGF‐β‐pathway genes ( NOTCH1 , HES1 , TGFB2 , TGFBR2 , and ID3 ) and reduction of ASCL1 and DLL3 , with some markers showing borderline significance (e.g., TGFBR2 P = 0.06) (Fig. 9j and Supplementary Fig. 18h, l ).