There is a highly significant association between article type and journal category (χ 2 = 527.15, P < 0.001), with collaborative articles being predominantly published in nonplastic surgery journals (n = 1534; 77.4%), whereas noncollaborative articles were almost exclusively published in plastic surgery journals (n = 2803; 99.6%).
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Among survivors aged 60 years or older, survival declined stepwise from robust to pre-frail to frail, with highly significant between-group differences (log-rank P < .001; Fig. 3 B).
Subgroup analyses were conducted for repeat PDT (Re-PDT) and secondary choroidal neovascularisation (CNV). Results Overall, PDT led to a significant improvement in visual acuity (p = 0.041) and a highly significant reduction in both CRT and SRF (each p < 0.001).
Intra-group analysis demonstrated highly significant reductions in CRP from baseline to Week 8 (Del-Immune V: p < 0.001; Control: p = 0.001).
Importantly, our multivariate analysis already adjusted for all major clinicopathological confounders (age, gender, smoking status, clinical stage, PD-L1), and the association between Ki-67 and MPR/pCR remained highly significant (adjusted OR per 1% increase = 1.069, P < 0.001), suggesting that the observed predictive value is robust against measured confounding.
Within both the single-detection and co-detection groups, all inflammatory markers showed highly significant differences between pre- and post-treatment values (all P<0.001), with consistent core trends: CRP, NLR, PLR, IBI and PWR were significantly reduced after treatment, whereas PLT was increased.
The obtained KMO value (0.621) indicated an acceptable sampling adequacy, while Bartlett’s test was highly significant (χ 2 = 126.05, p < 0.001), confirming that the correlation matrix was appropriate for multivariate analysis.
Tukey’s post hoc test showed a highly significant difference in thiocyanate levels between both smoked and smokeless tobacco users when compared to non-users ( p = 0.001).
The mean reduction of 4.60 ± 1.39 in the intervention group was highly significant relative to placebo (0.73 ± 1.38; p < 0.001).
Secondary Outcomes All PROs demonstrated highly significant improvements at the final follow-up compared with 2 preoperative baselines ( P < .001) ( Table 3 , Figure 4 ).
Statistical tests indicated significant cohort differences in employment rate [χ2(3) = 7.89, p = 0.048, Cramér’s V = 0.072] and highly significant differences in starting salary [F(3,1463) = 617.72, p < 0.001, η2 = 0.559], with the 2023 cohort showing a large effect size compared with the 2020 cohort.
Kaplan–Meier curves demonstrated highly significant separation across GNRI quartiles for MACE, all-cause death, and ischaemia-driven revascularisation (all log-rank P < 0.001), and a borderline trend for non-fatal myocardial infarction ( P = 0.064) ( Figures 2A–D ). 3.2.3.
Results Water physicochemical properties Electrical conductivity (EC), Ca + Mg, Na, HCO3, Cl, and SAR all indicated highly significant ( p < 0.001) changes between locations, according to a one-way ANOVA.
The comparisons between the clinical model and the cli-radiology model, the clinical model and the cli-pathology model, and the cli-radiology model and the combined model all demonstrated highly significant differences (all p < 0.001).
4 ) Predictors of overall vaccine hesitancy The final multiple regression model predicting Overall Vaccine Hesitancy scores was highly significant, F(15, 314) = 55.62, p < 0.001, accounting for a large proportion of variance (R2 = 0.73; adjusted R2 = 0.71).
When comparing trends between interportal and T‐capsulotomy utilization, a highly significant difference in response distributions between techniques over time was observed ( P < .001).
The Kolmogorov–Smirnov test revealed highly significant intergroup differences ( p < 0.001) in the distributions of TRIM5 , TRIM11 , TRIM21 , and TRIM72 .
Analysis by two‐way ANOVA revealed a highly significant Diet × PM 2.5 interaction ( p < 0.001).
Critically, the interaction was highly significant ( β = 0.29, Z = 4.07, p < 0.001, 95% CI = 0.15–0.44), indicating that the slope linking CsPIP output to subjective intensity differed across conditions.
Targeted module scoring of the ROS signaling pathway demonstrated a highly significant enrichment in OA chondrocytes compared to healthy controls (P < 0.001), directly corroborating our in vitro observations of intrinsic oxidative stress at the transcriptional level ( Fig.
Statistical analysis revealed highly significant differences from global reference values, with t -statistics ranging from 8.82 to 9.89 ( P -value ≤ 0.001), confirming the elevated and non-random nature of the measured concentrations.
The correlation between pulmonary RAI uptake score and treatment response remained highly significant (Spearman’s ρ = 0.664, p < 0.001).
palustre , florets per plant showed a highly significant Sex × Robustness interaction (ANOVA LRT: χ21 = 788.57, p < 0.001; Table S15 ).
The association between decreasing TST reactivity and increasing mortality demonstrated a highly significant trend (χ 2 test for trend: p < 0.001).
In contrast, miRNA-132 expression was lowest in HC (0.90 ± 0.63; 95% CI, 0.67 - 1.14), significantly increased in PD (2.50 ± 1.86; 95% CI, 1.74 - 3.26), and highest in T2DM (3.56 ± 2.04; 95% CI, 2.80 - 4.32), with highly significant differences between HC and PD and between HC and T2DM (P < 0.001), as well as between PD and T2DM (P = 0.045).