“highly significant”

In obese and nonobese patients, intake of glucose and glucose with NaCl showed no significant change in the levels of serum AngII and aldosterone which was associated a significant increase in serum Na in obese patients ( P = 0.03) and a highly significant reduction in serum K in nonobese patients ( P = 0.001).

All main effects were highly significant, including feed additive, day, and feed matrix ( P ≤ 0.001; Tables 2 and 3 ).

Compared to the Normal Control (NC) group, which exhibited basal physiological levels of these enzymes (MMP-1: 5.2±0.8 ng/mg protein; MMP-13: 3.9±0.6 ng/mg protein; ADAMTS-4: 2.3±0.4 ng/mg protein), the OA Control group displayed a highly significant (p < 0.001 for all) upregulation of MMP-1 (to 15.8±2.1 ng/mg protein, approximately a 3-fold increase), MMP-13 (to 12.5±1.7 ng/mg protein, approximately a 3.2-fold increase), and ADAMTS-4 (to 9.1±1.2 ng/mg protein, approximately a 3.95-fold increase).

The statistical analysis confirmed a highly significant difference between treatment groups (p < 0.001), establishing that the 65% higher capillary density achieved with HPTC treatment represents a genuine therapeutic advantage rather than random variation.

Overall, the regression model was highly significant [ F (1, 48) = 55.39, p < 0.001, R 2 = 0.53] and yielded a significant coefficient for trial (β = 0.02, t = 7.44, p < 0.001), which indicates that the difference across the two conditions increased logarithmically over time.

After adjustments, mean BMI for current international migrants was 23.3 kg/m 2 (95% CI 23.0–23.6), with highly significant differences from non-migrants (mean 20.9 kg/m 2 , 95% CI 20.7–21.0, difference = 2.4 kg/m 2 , p < 0.001) and internal migrants (mean 22.0 kg/m 2 , 95% CI 21.7–22.2, difference = 1.3 kg/m 2 , p < 0.001).

For N = 8, both PiCCL(4) and PiCCL(8) showed a statistically highly significant ( p ≤ 0.001 ) advantage over SimCLR, Barlow-Twins and SimSiam.

The differences were highly significant in the T-test (T = 17,4; p < 0,001).

After 7 days of treatment, the differences on MCF-7 tumor growth (Figure 3a ) became highly significant ( P < 0.001) and remained highly significant ( P < 0.001).

Log-linear model analysis of tail condition against site and sex showed that the interaction between site and tail condition, as well as site and sex, was not significant, but the interaction between tail condition and sex was highly significant ( Table 2 ; df =1; P =0.001).

The large effect size and highly significant ANOVA results (F(3,36) = 39.902, p < 0.001) support the robustness of the findings.

The model remained highly significant ( P < 0.001) also when validated using a binary logistic regression model, as described in Methods.

However, our reaction time analyses show that the difference between trial types was highly significant, t (47) = 3.77, p < .001, d = .15.

This difference was highly significant (χ2 = 134.751, p < .001), corroborating the findings of Wilmer et al. and Shujiao et al.

Comparisons between diabetic Groups (A and B) and the control group (C) were highly significant for both upper and lower premolars ( P < 0.001) [ Table 2 ].

Regarding external validity based on the relationship with another variable, we found that the overall score of the Collao Quechua WAST and the Patient Health Questionnaire (PHQ-9) show a direct, highly significant relationship and a moderate strength of relationship (Rho=0.618, p=0.001); this confirms external validity.

The effect of diet on ∆ δ 2 H DHA depletion was highly significant (all p < 0.001) for all tissue/lipid types (Figure 6B ).

A highly significant difference (P≤0.001) in the virus titer of treated versus untreated cells was calculated.

As expected, the repeated measures ANOVA showed a highly significant main effect for the network variable ( p < 0.001), indicating significant differences of CMRGlc values in the individual networks.

The ANOVA results indicate a highly significant variation in the decoupling index across the four regions (F = 14.63, p < 0.001), so establishing a statistical foundation for the formulation of regionally diversified energy strategies.

A highly significant difference was found in the mean numbers of modalities used before (mean = 0.48) and after (mean = 2.20) diagnosis ( T (324) = −11.73, P < .001).

Toma et al [ 78 ] found highly significant mean reductions in patients with both T1D and T2D for SBP (−3.47 mmHg, 95% CI −5.01 to −1.94; P <.001) and DBP (−1.84 mmHg, 95% CI −2.98 to −0.70; P =.002) because of Web- and mobile-based SNS interventions.

In addition, there was a highly significant relationship between doing the breastfeeding during work time and the duration of EBF for six months ( P < .001).

The differences between the values from the 3T3BXB-ER cells as well as the differences between 3T3 and 3T3BXB-ER cells were highly significant (p≤0.001), resulting in a decreased nuclear volume by ∼40% in estrogen treated BXB-ER cells.

There was a moderate and highly significant correlation between baseline LV GLS (−%) and follow-up LVEF (r = 0.717; p < 0.001).