“highly significant”

The difference observed between active (or inactive ) subdomains and repressed subdomains is statistically highly significant ( p < 1×10 −10 , Wilcoxon test).

cerebrum), there was a highly significant correlation ( r = 0.58; P = 1E-10) of methylation changes between the reported sites 29 and our study (Supplementary Fig.

A two-way analysis of variance (ANOVA) with bin and trial type (target or distractor in RF) as factors confirmed that there was a highly significant effect of time ( p < 10 −10 ) but no effect of trial type or interaction between time bin and trial type ( p > 0.1).

This difference was statistically highly significant ( p < 10 −10 ).

Despite the small size of the validation set (412 d ( P , T ) and 694 d ( P , P ) interactions), representing only 1% of the possible secondary regulatory interactions, PhosTF predicted 40% of the known d ( P , T ) and 28% of known d ( P , P ) interactions, which was highly significant ( p < 10 −10 ) when compared to the rate of predictions overall (20% and 18% respectively).

With weak ( m = 10 − 8 ) or strong introgression ( m = 10 − 7 ), on the other hand, the D -statistic was in the ranges of 0.04–0.31 and 0.33–0.73, respectively, and in all cases highly significant ( P < 10 − 10 ) ( Fig. 2b,c ).

A t-test comparing the means returns a p-value of 0.167 (no significant difference) while a 2 sample KS-test returns a highly significant (p-value <10 −10 ) difference between the two distributions.

Among these, we identified 339 genes, the expression levels for which showed highly significant (Moran’s I Bonferroni-corrected P < 1e-10) spatial heterogeneity across cells ( Dataset S11 ).

In an ANOVA with gain treated as a continuous regressor, the group effect for channels was highly significant (middle, p < 10 −10 ); lines connect channels that are not significantly different in post-hoc tests at level α =.05.

First, we found that the relationship between mean gene expression and CAI was highly significant and positive, as expected (adjusted R 2 = 0.27 , P < 10 − 10 , fig. 5 A and B ).

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).

The interaction term in a two-way ANOVA with space and shuffled/non-shuffled as factors was highly significant ( F = 15.51, p < 10 −10 ), implying that random spiking cannot fully account for increased feeder representation at the choice point.

Initially, we restricted our study to SNPs present in both studies with highly significant p -values for T1D and RPS26 eQTL ( p < 10 −10 in both cases).

Indeed, we observed a highly significant enrichment of H3K9 methylation at 49 known 26G loci ( Vasale et al. 2010 ) compared to 100 random genes ( P -value < 1 × 10 −10 ) ( Fig. 5C ).

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).

For genes from each cluster, he used a tool to run enrichment analysis and visually examined groupings of annotations that were highly significant (e.g. p ≤ 10 -10 ).

Notably, GO analysis of the 708 up-regulated genes did not show significant enrichment in any specific GO category, but the 733 down-regulated genes showed highly significant enrichment in several categories, with the top three (Benjamini adjusted P -value < 1 ×10 −10 ) classified as neural lineage related categories, including ‘neuron differentiation’, ‘transmission of nerve impulse’ and ‘neuron development’ (Figure 1D ).

The difference between the fraction of paused and non-paused genes containing GrIn1 elements was highly significant (χ 2 = 82; P < 10 −10 ).

Emmetropization There was strong evidence of emmetropization (Figures 4(a) and 4(b) ) in RAR and ROP Sprague-Dawley rats ( dashed light blue and light red lines ) as well as ROP Long-Evans rats ( dark red lines ) resulting in a highly significant effect of age ( F (age) = 32.6, df = 2,78, P < 10 −10 ).

This is highly significant ( p -value < 10 −10 ) at or beyond the α = 0.05 level.

Compared to the expectation under random assignment, this is an over-representation in this category of 40% in yeast and 29% in human, which is modest, but because of the large numbers, highly significant (both p<1e-10).

Eighteen of the highly significant ( p ‐value > 10 −10 ) associations were not near any a priori candidate genes.

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

This indeed revealed statistically highly significant (p < 1e-10) overrepresentation of genes encoding cytoplasmic ( AtMDL2 ) and plastid-specific ( AtMDL1 ) ribosomal proteins (Additional file 4 : Table S2; sheet “overrepresented BINs”).

Gene expression profiles of the mammary tumors for MMTV-cyclin D1 KE and MMTV-cyclin D1 WT mice showed highly significant overlap ( p < 1 × 10 −10 ) ( Supplementary Figure S9A–S9C and Dataset S2).