“highly significant”

Second, our study had excellent statistical power, yielding highly significant MR associations for IFNAR2 ( P =9.8×10 -11 ), increasing confidence in the validity of the much weaker signals for IFNAR2 reported in the GenOMICC study ( P =0.004), particularly as the earlier report had displayed evidence of confounding by LD ( P HEIDI = 0.015). 37 Indeed, compared to the analysi

The differences are highly significant (TT mean – TM mean: P = 9.99E − 11 ; TT mean – TM median: P = 0.0013, KS-test, two-sided, α = 0.05).

Initially, we restricted our study to SNPs present in both studies with highly significant p -values for T1D and RPS26 eQTL ( p < 10 −10 in both cases).

This revealed a moderate, but highly significant, correlation between responses to the two interventions in RCC4 cells (Pearson’s r = 0.33, P < 1 × 10 −10 , Fig. 3d left panel).

A category of Molecular Function (Chlorophyll binding; GO:0016168), three categories of Cellular Component (Chloroplast thylakoid membrane; GO:0009535, Photosys-tem II; GO:0009523, and Photosystem I; GO:0009522), and two categories of Biological Process (Protein chromophore linkage; GO:0018298, and Photosynthesis, light harvesting; GO:0009765) had a highly significant association (−log10 ( p -value) ≥ 10) in the down-regulated DEGs ( Fig. 3B ).

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

These differences in the proportion of observed gene conversion events in K a and in K s between the RP and MP groups are highly significant ( P < 10 −10 and P < 0.002, respectively; Fisher’s exact test).

We find a highly significant improvement in model performance (R 2 of 0.035 vs. 0.14, p < 10 −10 ). 3.2.

The downregulated modules include 170 genes ( p < 1e-06), among them 13 highly significant genes ( p < 1e-10): COL10A1 , SAMD9 , PLPP4 , COMP , POSTN , IGHV4–31 , THBS2 , MMP9 , FNDC1 , HOPX , TMEM200A , INHBA , and SULF1 .

The difference between the total scores of the study population (29) and the norm population in 1988 (35.79) was highly significant ( p < 10 −10 ) [ 1 ].

To further explore this relationship, we preformed a linear regression for Tup1 binding by the number of recruiter proteins bound and discovered a highly significant regression of R 2 = 0.500 (P<1×10 −10 ) ( Figure 2D ) .

This was largely due to a few eeQTLs with relatively highly significant effects ( p < 1e-10) on the expression levels of the 2nd exon in the milk cells and a similar but less significant effect ( p < 1e-4) on the 2nd exon expression in white blood cells (Additional file 2 : Figure S7).

This is highly significant ( p -value < 10 −10 ) at or beyond the α = 0.05 level.

We computed estimated axon conduction velocities from diameters of myelinated and unmyelinated fibers 28 along the proximal to distal axis and observed a strong and highly significant correlation (Fig. 2g , r 2 = 0.83, p < 10 − 10 ).

We observed highly significant enrichment for mQTL at CpGs in ME regions [odds ratio (OR), 6.2; P < 10 −10 , FET] but not in control regions (OR, 1.3; P = 0.09).

In this regard, the change in CD66b expression by bound cells was highly significant, p < 10 –10 and P < 10 –5 compared to BSL and CIRC respectively (Fig. 3 c).

This represented a highly significant overall decline in the inheritance of BMI with increasing exercise (P<10 −10 ).

In both cases the difference is highly significant ( P << 10 −10 ).

Figure 1 C shows across 9,320 gene promoters, RNA Pol II pauses at very similar locations among the five individuals; pairwise correlations ( Figure 1 D) are highly significant (p < 10 −10 ).

Relatively large and highly significant interaction effects were found in the gradients of WF ( β PD = 0.46, 95% CI = [0.33, 0.59], P < 10 −10 ) and R2* ( β PD = -0.47, 95% CI = [−0.63, -0.32], P < 10 −7 ).

Notably, magnesium, potassium, Folate, and vitamins A, C and E demonstrated highly significant associations with Prudent dietary adherence ( p < 1 × 10− 10 ), consistent with their known roles in oxidative stress, inflammation, and vascular health [ 67 ].

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).

Matrix‐like voxels continued to show higher movement‐related activation than striosome‐like voxels across all body parts (left foot, left hand, right foot, right hand, tongue), with highly significant differences in every condition (all p < 10 −10 ).

On the basis of counting statistics (binomial distribution), this difference is highly significant ( p << 10 −10 ).

When plotting the solubility and disorder scores at neutral pH (pH = 7.0), a highly significant linear correlation was observed between these two variables (R 2 = 0.90, p < 1 −10 ) ( Figure 3 ), suggesting that solubility and disorder are intimately ligated in this dataset.